ZNF274 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000171606 T095107_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZNF274
M04549_2.00		 Homo sapiens
NVYGAGRACTCAYRYN
NRYRTGAGTYCTCRBN		 SELEX
Yin et al.(2017)
ZNF274_eDBD_HT-SELEX		 (Direct) (Direct)
ZNF274
M04550_2.00		 Homo sapiens
NVHGAGRACTCAYRYN
NRYRTGAGTYCTCDBN		 SELEX
Yin et al.(2017)
ZNF274_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
ZNF274
M07632_2.00		 Homo sapiens
CWGTRTGARTTCTCW
WGAGAAYTCAYACWG		 ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF274.RCADE.ReprocessedData		 (Direct) (Direct)
ZNF274
M07933_2.00		 Homo sapiens
YTTCTCHCCAGTRTGAR
YTCAYACTGGDGAGAAR		 ChIP-seq
Gerstein et al.(2012)
HeLa-S3_ZNF274_UCD		 (Direct) (Direct)
ZNF274
M07934_2.00		 Homo sapiens
GGTTTYTCTCCAGTR
YACTGGAGARAAACC		 ChIP-seq
Gerstein et al.(2012)
HepG2b_ZNF274_UCD		 (Direct) (Direct)
ZNF274
M07935_2.00		 Homo sapiens
GAGAAYTCAYACTGG
CCAGTRTGARTTCTC		 ChIP-seq
Gerstein et al.(2012)
K562b_ZNF274_UCD		 (Direct) (Direct)
ZNF274
M07936_2.00		 Homo sapiens
TTYTCTCCAGTRTGA
TCAYACTGGAGARAA		 ChIP-seq
Gerstein et al.(2012)
NT2-D1_ZNF274_UCD		 (Direct) (Direct)
ZNF274
M08916_2.00		 Homo sapiens
TWNGRTTTCTYTCCAKTRTG
CAYAMTGGARAGAAAYCNWA		 Misc
Kulakovskiy et al.(2013)
ZN274_HUMAN.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000321187 C2H2 ZF 475 497
ENSP00000321187 C2H2 ZF 503 525
ENSP00000321187 C2H2 ZF 531 553
ENSP00000321187 C2H2 ZF 559 581
ENSP00000321187 C2H2 ZF 587 609
ENSP00000321209 C2H2 ZF 465 487
ENSP00000321209 C2H2 ZF 493 515
ENSP00000321209 C2H2 ZF 521 543
ENSP00000321209 C2H2 ZF 549 571
ENSP00000321209 C2H2 ZF 577 599
ENSP00000409872 C2H2 ZF 402 424
ENSP00000409872 C2H2 ZF 430 452
ENSP00000409872 C2H2 ZF 458 480
ENSP00000409872 C2H2 ZF 486 508
ENSP00000409872 C2H2 ZF 514 536
ENSP00000478533 C2H2 ZF 507 529
ENSP00000478533 C2H2 ZF 535 557
ENSP00000478533 C2H2 ZF 563 585
ENSP00000478533 C2H2 ZF 591 613
ENSP00000478533 C2H2 ZF 619 641
ENSP00000484810 C2H2 ZF 507 529
ENSP00000484810 C2H2 ZF 535 557
ENSP00000484810 C2H2 ZF 563 585
ENSP00000484810 C2H2 ZF 591 613
ENSP00000484810 C2H2 ZF 619 641

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

27 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPPYG00000010493 Pongo abelii ENSPPYG00000010493 I 0.827
ZNF274 Gorilla gorilla ENSGGOG00000004688 I 0.827
ENSNLEG00000011103 Nomascus leucogenys ENSNLEG00000011103 I 0.827
ZNF274 Pan troglodytes ENSPTRG00000011583 I 0.827
ZNF544 Callithrix jacchus ENSCJAG00000000329 I 0.827
ENSPANG00000012245 Papio anubis ENSPANG00000012245 I 0.825
ENSCSAG00000019664 Chlorocebus sabaeus ENSCSAG00000019664 I 0.825
ZNF274 Macaca mulatta ENSMMUG00000020505 I 0.823
ENSP00000409872 Macaca fascicularis ENSP00000409872 I 0.823
ZNF274 Otolemur garnettii ENSOGAG00000005637 I 0.802
ZNF274 Microcebus murinus ENSMICG00000017855 I 0.802
ENSTSYG00000010913 Tarsius syrichta ENSTSYG00000010913 I 0.801
ZNF274 Equus caballus ENSECAG00000007526 I 0.800
ZNF274 Tursiops truncatus ENSTTRG00000013077 I 0.800
ENSMPUG00000008378 Mustela putorius furo ENSMPUG00000008378 I 0.798
ZNF274 Sus scrofa ENSSSCG00000003998 I 0.793
ZNF274 Dasypus novemcinctus ENSDNOG00000032910 I 0.792
ZNF274 Sorex araneus ENSSARG00000001423 I 0.790
ZNF274 Tupaia belangeri ENSTBEG00000006394 I 0.790
ZNF274 Pteropus vampyrus ENSPVAG00000002938 I 0.783
ZNF274 Ochotona princeps ENSOPRG00000007383 I 0.783
ZNF274 Erinaceus europaeus ENSEEUG00000008228 I 0.781
ZNF274 Bos taurus ENSBTAG00000013353 I 0.778
Myotis_brandtii_ZNF274_10003422 Myotis brandtii Myotis_brandtii_ZNF274_10003422 I 0.771
Zfp110 Mus musculus ENSMUSG00000058638 I 0.758
Zfp110 Rattus norvegicus ENSRNOG00000031328 I 0.757