KLF11 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000172059 T095116_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
KLF11
M00241_2.00
Homo sapiens
MCGCCCMC

GKGGGCGK
PBM
Barrera et al.(2016)
KLF11_R402Q
(Direct) (Direct)
KLF11
M00242_2.00
Homo sapiens
MCGCCCCC

GGGGGCGK
PBM
Barrera et al.(2016)
KLF11_REF
(Direct) (Direct)
KLF11
M04554_2.00
Homo sapiens
VMCMCRCCCMYNMCACGCCCMC

GKGGGCGTGKNRKGGGYGKGKB
SELEX
Yin et al.(2017)
KLF11_eDBD_HT-SELEX
(Direct) (Direct)
KLF11
M04555_2.00
Homo sapiens
VMCMCRCCCHYNHCACGCCCMC

GKGGGCGTGDNRDGGGYGKGKB
SELEX
Yin et al.(2017)
KLF11_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
KLF11
M10261_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$FKLF_Q5
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
KLF10
M04489_2.00
Homo sapiens
RMCACRCCCMYVHCACRCCCMC

GKGGGYGTGDBRKGGGYGTGKY
SELEX
Yin et al.(2017)
KLF10_eDBD_HT-SELEX
0.775 0.855
KLF10
M08246_2.00
Homo sapiens
RCCMCRCCCH

DGGGYGKGGY
ChIP-seq
Najafabadi et al.(2015b)
KLF10
0.775 0.855
KLF10
M08317_2.00
Homo sapiens
SMCMCRCCCMYNBSN

NSVNRKGGGYGKGKS
ChIP-seq
Schmitges et al.(2016)
Q13118.MEME
0.775 0.855
KLF10
M10228_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TIEG1_Q6
0.775 0.855
KLF10
M04490_2.00
Homo sapiens
RMCACRCCCMYGMCACRCCCHC

GDGGGYGTGKCRKGGGYGTGKY
SELEX
Yin et al.(2017)
KLF10_eDBD_Methyl-HT-SELEX
0.775 0.855
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00241_2.00 C2H2 ZF 15 39
M00241_2.00 C2H2 ZF 45 69
M00241_2.00 C2H2 ZF 75 97
M00242_2.00 C2H2 ZF 15 39
M00242_2.00 C2H2 ZF 45 69
M00242_2.00 C2H2 ZF 75 97

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000307023 C2H2 ZF 394 418
ENSP00000307023 C2H2 ZF 424 448
ENSP00000307023 C2H2 ZF 454 476
ENSP00000442722 C2H2 ZF 377 401
ENSP00000442722 C2H2 ZF 407 431
ENSP00000442722 C2H2 ZF 437 459
ENSP00000444690 C2H2 ZF 377 401
ENSP00000444690 C2H2 ZF 407 431
ENSP00000444690 C2H2 ZF 437 459

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

171 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
KLF11 Dasypus novemcinctus ENSDNOG00000035689 I 0.827
KLF11 Gorilla gorilla ENSGGOG00000012494 I 0.827
KLF11 Pan troglodytes ENSPTRG00000011645 I 0.827
ENSSTOG00000002442 Ictidomys tridecemlineatus ENSSTOG00000002442 I 0.827
ENSCSAG00000007163 Chlorocebus sabaeus ENSCSAG00000007163 I 0.827
ENSPANG00000008644 Papio anubis ENSPANG00000008644 I 0.827
KLF11 Monodelphis domestica ENSMODG00000014758 I 0.824
KLF11 Ornithorhynchus anatinus ENSOANG00000007790 I 0.824
KLF11 Loxodonta africana ENSLAFG00000032182 I 0.824
ENSSHAG00000005846 Sarcophilus harrisii ENSSHAG00000005846 I 0.824
KLF11 Felis catus ENSFCAG00000030965 I 0.824
ENSAMEG00000011355 Ailuropoda melanoleuca ENSAMEG00000011355 I 0.820
KLF11 Otolemur garnettii ENSOGAG00000026035 I 0.811
ENSNLEG00000013701 Nomascus leucogenys ENSNLEG00000013701 I 0.811
ENSP00000307023 Macaca fascicularis ENSP00000307023 I 0.811
KLF11 Macaca mulatta ENSMMUG00000002054 I 0.811
ENSPPYG00000012659 Pongo abelii ENSPPYG00000012659 I 0.811
KLF11 Ochotona princeps ENSOPRG00000013425 I 0.808
KLF11 Oryzias latipes ENSORLG00000015191 I 0.808
KLF11 Procavia capensis ENSPCAG00000011366 I 0.808
KLF11 Oryctolagus cuniculus ENSOCUG00000003809 I 0.808
Klf11 Mus musculus ENSMUSG00000020653 I 0.808
ENSOARG00000015319 Ovis aries ENSOARG00000015319 I 0.808
KLF11 Echinops telfairi ENSETEG00000002915 I 0.808
KLF11 Gasterosteus aculeatus ENSGACG00000008836 I 0.808
ENSONIG00000003704 Oreochromis niloticus ENSONIG00000003704 I 0.808
ENSAMXG00000004794 Astyanax mexicanus ENSAMXG00000004794 I 0.808
KLF11 Bos taurus ENSBTAG00000046218 I 0.808
KLF11 Tursiops truncatus ENSTTRG00000017207 I 0.808
ENSP00000307023-D1 Bos grunniens ENSP00000307023-D1 I 0.808
Klf11 Rattus norvegicus ENSRNOG00000054259 I 0.808
KLF11 Takifugu rubripes ENSTRUG00000013598 I 0.808
KLF11 Equus caballus ENSECAG00000015820 I 0.808
KLF11 Canis familiaris ENSCAFG00000003405 I 0.804
KLF11 Tupaia belangeri ENSTBEG00000008268 I 0.804
klf11a Danio rerio ENSDARG00000030844 I 0.804
ENSGMOG00000011144 Gadus morhua ENSGMOG00000011144 I 0.804
ENSAMXG00000011768 Astyanax mexicanus ENSAMXG00000011768 I 0.804
klf11b Danio rerio ENSDARG00000013794 I 0.804
ENSXMAG00000009885 Xiphophorus maculatus ENSXMAG00000009885 I 0.801
ENSGMOG00000003463 Gadus morhua ENSGMOG00000003463 I 0.801
KLF11 Tetraodon nigroviridis ENSTNIG00000000881 I 0.801
KLF11 Takifugu rubripes ENSTRUG00000008202 I 0.801
KLF11 Oryzias latipes ENSORLG00000018102 I 0.801
ENSONIG00000018808 Oreochromis niloticus ENSONIG00000018808 I 0.801
KLF11 Gasterosteus aculeatus ENSGACG00000001487 I 0.801
ENSPFOG00000015744 Poecilia formosa ENSPFOG00000015744 I 0.801
ENSMEUG00000015111 Macropus eugenii ENSMEUG00000015111 I 0.800
ENSMPUG00000013287 Mustela putorius furo ENSMPUG00000013287 I 0.800
KLF11 Sorex araneus ENSSARG00000004298 I 0.795
ENSXMAG00000010947 Xiphophorus maculatus ENSXMAG00000010947 I 0.795
ENSPFOG00000005130 Poecilia formosa ENSPFOG00000005130 I 0.795
ENSDORG00000012974 Dipodomys ordii ENSDORG00000012974 I 0.795
KLF11 Pteropus vampyrus ENSPVAG00000017463 I 0.794
Myotis_brandtii_KLF11_10020832 Myotis brandtii Myotis_brandtii_KLF11_10020832 I 0.792
Brh_R012523 Buceros rhinoceros Brh_R012523 I 0.792
KLF11 Myotis lucifugus ENSMLUG00000002295 I 0.792
Pvit_14441 Pogona vitticeps Pvit_14441 I 0.792
ENSFALG00000006648 Ficedula albicollis ENSFALG00000006648 I 0.792
KLF11 Erinaceus europaeus ENSEEUG00000006894 I 0.792
KLF11 Anolis carolinensis ENSACAG00000000128 I 0.792
KLF10 Erinaceus europaeus ENSEEUG00000009077 I 0.791
ENSGALG00000016063 Gallus gallus ENSGALG00000016063 I 0.791
Aan_R003929 Calypte anna Aan_R003929 I 0.791
ENSPSIG00000010816 Pelodiscus sinensis ENSPSIG00000010816 I 0.788
Alligator_sinensis_CCG017491.1 Alligator sinensis Alligator_sinensis_CCG017491.1 I 0.788
klf11 Xenopus tropicalis XB-GENE-956858 I 0.788
klf11.L Xenopus laevis XB-GENE-956865 I 0.788
klf11.S Xenopus laevis XB-GENE-17345045 I 0.788
Tal_R013154 Tyto alba Tal_R013154 I 0.788
Afo_R015752 Aptenodytes forsteri Afo_R015752 I 0.788
ENSAPLG00000009146 Anas platyrhynchos ENSAPLG00000009146 I 0.788
Aan_R015392 Calypte anna Aan_R015392 I 0.788
KLF11 Taeniopygia guttata ENSTGUG00000013041 I 0.788
KLF11 Gallus gallus ENSGALG00000016440 I 0.788
KLF11 Meleagris gallopavo ENSMGAG00000014008 I 0.788
ENSLACG00000010260 Latimeria chalumnae ENSLACG00000010260 I 0.788
ENSLOCG00000016837 Lepisosteus oculatus ENSLOCG00000016837 I 0.788
klf10.L Xenopus laevis XB-GENE-17335049 I 0.787
ENSAPLG00000004145 Anas platyrhynchos ENSAPLG00000004145 I 0.787
Pvit_03838 Pogona vitticeps Pvit_03838 I 0.787
klf10 Xenopus tropicalis XB-GENE-854761 I 0.787
KLF10 Meleagris gallopavo ENSMGAG00000012319 I 0.787
klf10.S Xenopus laevis XB-GENE-866571 I 0.787
KLF10 Anolis carolinensis ENSACAG00000009177 I 0.787
Gfo_R015265 Geospiza fortis Gfo_R015265 I 0.782
estExt_fgenesh2_pg.C_5760011 Branchiostoma floridae estExt_fgenesh2_pg.C_5760011 I 0.780
PHUM248360 Pediculus humanus PHUM248360 I 0.777
Sakowv30032823m.g Saccoglossus kowalevskii Sakowv30032823m.g I 0.776
Ogr04283 Ophisaurus gracilis Ogr04283 I 0.776
KLF10 Canis familiaris ENSCAFG00000000638 I 0.775
KLF10 Oryctolagus cuniculus ENSOCUG00000016141 I 0.775
KLF10 Callithrix jacchus ENSCJAG00000016069 I 0.775
ENSTSYG00000003347 Tarsius syrichta ENSTSYG00000003347 I 0.775
ENSCSAG00000011934 Chlorocebus sabaeus ENSCSAG00000011934 I 0.775
ENSAMEG00000014775 Ailuropoda melanoleuca ENSAMEG00000014775 I 0.775
ENSMPUG00000015132 Mustela putorius furo ENSMPUG00000015132 I 0.775
KLF10 Tursiops truncatus ENSTTRG00000000383 I 0.775
KLF10 Macaca mulatta ENSMMUG00000018815 I 0.775
ENSP00000285407 Macaca fascicularis ENSP00000285407 I 0.775
ENSMEUG00000000662 Macropus eugenii ENSMEUG00000000662 I 0.775
Tal_R007530 Tyto alba Tal_R007530 I 0.775
ENSBTAP00000019142-D1 Bos grunniens ENSBTAP00000019142-D1 I 0.775
KLF10 Monodelphis domestica ENSMODG00000005896 I 0.775
ENSLACG00000013560 Latimeria chalumnae ENSLACG00000013560 I 0.775
KLF10 Loxodonta africana ENSLAFG00000000037 I 0.775
Brh_R008046 Buceros rhinoceros Brh_R008046 I 0.775
Afo_R002224 Aptenodytes forsteri Afo_R002224 I 0.775
KLF10 Bos taurus ENSBTAG00000014396 I 0.775
KLF10 Gorilla gorilla ENSGGOG00000015206 I 0.775
ENSPPYG00000018800 Pongo abelii ENSPPYG00000018800 I 0.775
DAPPUDRAFT_312628 Daphnia pulex DAPPUDRAFT_312628 I 0.775
KLF10 Pan troglodytes ENSPTRG00000020484 I 0.775
ENSNLEG00000003646 Nomascus leucogenys ENSNLEG00000003646 I 0.775
KLF10 Pteropus vampyrus ENSPVAG00000013271 I 0.775
KLF10 Ornithorhynchus anatinus ENSOANG00000013800 I 0.775
KLF10 Echinops telfairi ENSETEG00000016283 I 0.775
KLF10 Homo sapiens ENSG00000155090 D 0.775
KLF10 Otolemur garnettii ENSOGAG00000014528 I 0.775
KLF10 Ochotona princeps ENSOPRG00000006656 I 0.775
KLF10 Felis catus ENSFCAG00000026958 I 0.775
ENSPANG00000009227 Papio anubis ENSPANG00000009227 I 0.775
ENSOARG00000017131 Ovis aries ENSOARG00000017131 I 0.775
Klf10 Rattus norvegicus ENSRNOG00000006118 I 0.775
KLF10 Equus caballus ENSECAG00000013153 I 0.775
ENSSHAG00000018290 Sarcophilus harrisii ENSSHAG00000018290 I 0.775
ENSSSCG00000027819 Sus scrofa ENSSSCG00000027819 I 0.775
ENSSTOG00000027022 Ictidomys tridecemlineatus ENSSTOG00000027022 I 0.775
KLF10 Dasypus novemcinctus ENSDNOG00000017020 I 0.775
KLF10 Sus scrofa ENSSSCG00000027480 I 0.775
Klf10 Mus musculus ENSMUSG00000037465 I 0.775
Klf10 Dipodomys ordii ENSDORG00000015269 I 0.775
Myotis_brandtii_KLF10_10032162 Myotis brandtii Myotis_brandtii_KLF10_10032162 I 0.771
KLF10 Myotis lucifugus ENSMLUG00000012969 I 0.771
Alligator_sinensis_CCG001309.1 Alligator sinensis Alligator_sinensis_CCG001309.1 I 0.771
KLF10 Cavia porcellus ENSCPOG00000011105 I 0.771
ENSFALG00000005917 Ficedula albicollis ENSFALG00000005917 I 0.771
Gfo_R006024 Geospiza fortis Gfo_R006024 I 0.771
ENSMICG00000002285 Microcebus murinus ENSMICG00000002285 I 0.771
ENSPMAG00000001515 Petromyzon marinus ENSPMAG00000001515 I 0.771
ENSPSIG00000012678 Pelodiscus sinensis ENSPSIG00000012678 I 0.771
Cmyd_10010871 Chelonia mydas Cmyd_10010871 I 0.771
ENSCSAVG00000009024 Ciona savignyi ENSCSAVG00000009024 I 0.770
tetur19g01530 Tetranychus urticae tetur19g01530 I 0.770
SPU_026418 Strongylocentrotus purpuratus SPU_026418 I 0.768
TriadG27838 Trichoplax adhaerens TriadG27838 I 0.767
AARA003888 Anopheles arabiensis AARA003888 I 0.766
AALB000668 Anopheles albimanus AALB000668 I 0.766
AMIN009608 Anopheles minimus AMIN009608 I 0.766
ACOM026746 Anopheles coluzzii ACOM026746 I 0.766
AFUN003293 Anopheles funestus AFUN003293 I 0.766
AFAF014334 Anopheles farauti AFAF014334 I 0.766
ACUA013995 Anopheles culicifacies ACUA013995 I 0.766
AATE015094 Anopheles atroparvus AATE015094 I 0.766
ENSXMAG00000002425 Xiphophorus maculatus ENSXMAG00000002425 I 0.766
AGAP009889 Anopheles gambiae AGAP009889 I 0.766
ASIS021840 Anopheles sinensis ASIS021840 I 0.766
ENSPFOG00000013334 Poecilia formosa ENSPFOG00000013334 I 0.766
KLF10 Gasterosteus aculeatus ENSGACG00000004632 I 0.766
AMEM009801 Anopheles merus AMEM009801 I 0.766
AMAM002233 Anopheles maculatus AMAM002233 I 0.766
ASTEI06573 Anopheles stephensi ASTEI06573 I 0.766
ENSONIG00000016428 Oreochromis niloticus ENSONIG00000016428 I 0.766
KLF10 Taeniopygia guttata ENSTGUG00000012120 I 0.765
D915_00578 Fasciola hepatica D915_00578 I 0.764
ISCW022767 Ixodes scapularis ISCW022767 I 0.761
ENSLOCG00000006468 Lepisosteus oculatus ENSLOCG00000006468 I 0.761
GB45040 Apis mellifera GB45040 I 0.760
CapteG30011 Capitella teleta CapteG30011 I 0.758
XP_002161066.1 Hydra magnipapillata XP_002161066.1 I 0.757