HIC1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000177374 T095155_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
HIC1
M04568_2.00
Homo sapiens
NRTGCCMMCN

NGKKGGCAYN
SELEX
Yin et al.(2017)
HIC1_eDBD_HT-SELEX
(Direct) (Direct)
HIC1
M04569_2.00
Homo sapiens
NRTGCCMMCN

NGKKGGCAYN
SELEX
Yin et al.(2017)
HIC1_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
HIC1
M08924_2.00
Homo sapiens
KGGCAMCCH

DGGKTGCCM
Misc
Kulakovskiy et al.(2013)
HIC1_HUMAN.H11MO.0.C
(Direct) (Direct)
HIC1
M10265_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIC1_02
(Direct) (Direct)
HIC1
M10266_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIC1_03
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000314080 C2H2 ZF 507 529
ENSP00000314080 C2H2 ZF 535 557
ENSP00000314080 C2H2 ZF 563 585
ENSP00000314080 C2H2 ZF 591 613
ENSP00000382742 C2H2 ZF 488 510
ENSP00000382742 C2H2 ZF 516 538
ENSP00000382742 C2H2 ZF 544 566
ENSP00000382742 C2H2 ZF 572 594
ENSP00000477858 C2H2 ZF 488 510
ENSP00000477858 C2H2 ZF 516 538
ENSP00000477858 C2H2 ZF 544 566
ENSP00000477858 C2H2 ZF 572 594

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

34 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
HIC1 Procavia capensis ENSPCAG00000000535 I 0.827
ENSPPYG00000007789 Pongo abelii ENSPPYG00000007789 I 0.827
ENSPANG00000024595 Papio anubis ENSPANG00000024595 I 0.827
HIC1 Otolemur garnettii ENSOGAG00000034845 I 0.827
Myotis_brandtii_HIC1_10015709 Myotis brandtii Myotis_brandtii_HIC1_10015709 I 0.827
ENSMPUG00000019502 Mustela putorius furo ENSMPUG00000019502 I 0.827
ENSPTRG00000008543 Pan troglodytes ENSPTRG00000008543 I 0.827
HIC1 Pteropus vampyrus ENSPVAG00000002158 I 0.827
HIC1 Sus scrofa ENSSSCG00000025717 I 0.827
ENSSTOG00000011792 Ictidomys tridecemlineatus ENSSTOG00000011792 I 0.827
HIC1 Sorex araneus ENSSARG00000010162 I 0.827
LOC100912068 Rattus norvegicus ENSRNOG00000057619 I 0.827
Hic1 Rattus norvegicus ENSRNOG00000046405 I 0.827
ENSMMUG00000030393 Macaca mulatta ENSMMUG00000030393 I 0.827
ENSAMEG00000007657 Ailuropoda melanoleuca ENSAMEG00000007657 I 0.827
HIC1 Myotis lucifugus ENSMLUG00000010527 I 0.827
HIC1 Gorilla gorilla ENSGGOG00000027584 I 0.827
ENSDORG00000016613 Dipodomys ordii ENSDORG00000016613 I 0.827
HIC1 Dasypus novemcinctus ENSDNOG00000049226 I 0.827
ENSCSAG00000013805 Chlorocebus sabaeus ENSCSAG00000013805 I 0.827
HIC1 Canis familiaris ENSCAFG00000019257 I 0.827
HIC1 Bos taurus ENSBTAG00000025130 I 0.827
HIC1 Loxodonta africana ENSLAFG00000001259 I 0.827
hic1 Danio rerio ENSDARG00000055493 I 0.822
ENSAMXG00000024869 Astyanax mexicanus ENSAMXG00000024869 I 0.822
ENSLOCG00000006478 Lepisosteus oculatus ENSLOCG00000006478 I 0.822
ENSXMAG00000001419 Xiphophorus maculatus ENSXMAG00000001419 I 0.816
ENSPFOG00000004471 Poecilia formosa ENSPFOG00000004471 I 0.816
ENSONIG00000021060 Oreochromis niloticus ENSONIG00000021060 I 0.816
HIC1 Microcebus murinus ENSMICG00000012908 I 0.815
ENSGMOG00000011705 Gadus morhua ENSGMOG00000011705 I 0.796
ENSNLEG00000000203 Nomascus leucogenys ENSNLEG00000000203 I 0.791
HIC2 Monodelphis domestica ENSMODG00000017662 I 0.789