ZBTB33 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000177485 T095156_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZBTB33
M04570_2.00
Homo sapiens
BRTTATGTTAAAWKDGCGYB

VRCGCHMWTTTAACATAAYV
SELEX
Yin et al.(2017)
ZBTB33_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
ZBTB33
M08094_2.00
Homo sapiens
BTCTCGCGRKRBYBN

NVRVYMYCGCGAGAV
ChIP-seq
Mathelier et al.(2014)
MA0527.1
(Direct) (Direct)
ZBTB33
M08925_2.00
Homo sapiens
NTCTCGCGRKVBYNS

SNRVBMYCGCGAGAN
Misc
Kulakovskiy et al.(2013)
KAISO_HUMAN.H11MO.0.A
(Direct) (Direct)
ZBTB33
M09511_2.00
Homo sapiens
SVNTCTCGCGAGANB

VNTCTCGCGAGANBS
Misc
Heinz et al.(2010)
GM12878-ZBTB33_GSE32465
(Direct) (Direct)
ZBTB33
M10267_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$KAISO_01
(Direct) (Direct)
ZBTB33
M10268_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$KAISO_Q2
(Direct) (Direct)
ZBTB33
M10269_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZBTB33_01
(Direct) (Direct)
ZBTB33
M10270_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZBTB33_03
(Direct) (Direct)
ZBTB33
M10271_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZBTB33_04
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000314153 C2H2 ZF 493 515
ENSP00000314153 C2H2 ZF 521 543
ENSP00000314153 C2H2 ZF 549 572
ENSP00000450969 C2H2 ZF 493 515
ENSP00000450969 C2H2 ZF 521 543
ENSP00000450969 C2H2 ZF 549 572

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found