EGR3 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000179388 T095176_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
EGR3
M02915_2.00
Homo sapiens
NHMCGCCCMCGCAHN

NDTGCGKGGGCGKDN
SELEX
Jolma et al.(2013)
EGR3_1
(Direct) (Direct)
EGR3
M04583_2.00
Homo sapiens
HMCGCCCACGCRH

DYGCGTGGGCGKD
SELEX
Yin et al.(2017)
EGR3_FL_HT-SELEX
(Direct) (Direct)
EGR3
M04584_2.00
Homo sapiens
NMCGCCCACGCRH

DYGCGTGGGCGKN
SELEX
Yin et al.(2017)
EGR3_FL_Methyl-HT-SELEX
(Direct) (Direct)
EGR3
M08349_2.00
Homo sapiens
CDCCYCCDC

GHGGRGGHG
ChIP-seq
Schmitges et al.(2016)
Q06889_1-3.RCADE
(Direct) (Direct)
EGR3
M10279_2.00
Homo sapiens
MCGCCYACGCWN

NWGCGTRGGCGK
Transfac
Matys et al.(2006)
V$EGR3_01
(Direct) (Direct)
EGR3
M10280_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR3_Q3
(Direct) (Direct)
EGR3
M10281_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR3_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Egr3
M00776_2.00
Mus musculus
HHDCCCMCDN

NHGKGGGHDD
PBM
Weirauch et al.(2013)
pTH2820
0.827 1.000
Egr3
M02931_2.00
Mus musculus
HMCGCCCACGCAHWN

NWDTGCGTGGGCGKD
SELEX
Jolma et al.(2013)
Egr3_1
0.827 1.000
Egr1
M01864_2.00
Mus musculus
CCCMCGYNN

NNRCGKGGG
PBM
Weirauch et al.(2014)
pTH5337
0.816 0.899
Egr1
M00375_2.00
Mus musculus
NCCYMCDNN

NNHGKRGGN
PBM
Berger et al.(2006)
Zif268
0.816 0.899
EGR1
M02883_2.00
Homo sapiens
NMCGCCCMCGCANN

NNTGCGKGGGCGKN
SELEX
Jolma et al.(2013)
EGR1_1
0.816 0.899
EGR1
M02884_2.00
Homo sapiens
HMCGCCCACGCAHW

WDTGCGTGGGCGKD
SELEX
Jolma et al.(2013)
EGR1_2
0.816 0.899
Egr1
M02932_2.00
Mus musculus
HHMCGCCCMCBCAHHH

DDDTGVGKGGGCGKDD
SELEX
Jolma et al.(2013)
Egr1_1
0.816 0.899
EGR1
M04437_2.00
Homo sapiens
NNCRCCCMCRCNN

NNGYGKGGGYGNN
SELEX
Yin et al.(2017)
EGR1_eDBD_HT-SELEX
0.816 0.899
Egr1
M05860_2.00
Mus musculus
NNMCRCCCMCGCN

NGCGKGGGYGKNN
SMiLE-seq
Isakova et al.(2017)
EGR1
0.816 0.899
EGR1
M07927_2.00
Homo sapiens
NVBNNNNBCCGCCCMCGCNB

VNGCGKGGGCGGVNNNNVBN
ChIP-seq
Gerstein et al.(2012)
GM12878_EGR1_HudsonAlpha
0.816 0.899
EGR1
M07928_2.00
Homo sapiens
BNCCGCCCMCGCNBB

VVNGCGKGGGCGGNV
ChIP-seq
Gerstein et al.(2012)
H1-hESC_EGR1_HudsonAlpha
0.816 0.899
EGR1
M07929_2.00
Homo sapiens
NNNNNNBNNCCRCCCMCGCN

NGCGKGGGYGGNNVNNNNNN
ChIP-seq
Gerstein et al.(2012)
K562_EGR1_HudsonAlpha
0.816 0.899
EGR1
M08882_2.00
Homo sapiens
BHNCCDCCCMCDCHBNB

VNVDGHGKGGGHGGNDV
Misc
Kulakovskiy et al.(2013)
EGR1_HUMAN.H11MO.0.A
0.816 0.899
Egr1
M08996_2.00
Mus musculus
YYCCRCCCMCGCNB

VNGCGKGGGYGGRR
Misc
Kulakovskiy et al.(2013)
EGR1_MOUSE.H11MO.0.A
0.816 0.899
EGR1
M09506_2.00
Homo sapiens
CRCCCMCRCA

TGYGKGGGYG
Misc
Heinz et al.(2010)
K562-Egr1_GSE32465
0.816 0.899
EGR1
M10188_2.00
Homo sapiens
MCGCCYACGCAW

WTGCGTRGGCGK
Transfac
Matys et al.(2006)
V$EGR1_01
0.816 0.899
EGR1
M10189_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_02
0.816 0.899
EGR1
M10190_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_09
0.816 0.899
EGR1
M10191_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_11
0.816 0.899
EGR1
M10192_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_12
0.816 0.899
EGR1
M10193_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_13
0.816 0.899
EGR1
M10194_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_15
0.816 0.899
EGR1
M10195_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_Q3
0.816 0.899
EGR1
M10196_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_Q6
0.816 0.899
EGR1
M04438_2.00
Homo sapiens
NHCDCCCMCNYNN

NNRNGKGGGHGDN
SELEX
Yin et al.(2017)
EGR1_eDBD_Methyl-HT-SELEX
0.816 0.899
EGR2
M00233_2.00
Homo sapiens
HDCCCMCDBN

NVHGKGGGHD
PBM
Barrera et al.(2016)
EGR2_REF
0.804 0.899
Egr2
M00778_2.00
Mus musculus
YRCCCMCGYN

NRCGKGGGYR
PBM
Weirauch et al.(2013)
pTH3091
0.804 0.899
EGR2
M02885_2.00
Homo sapiens
MCGCCCACGCD

HGCGTGGGCGK
SELEX
Jolma et al.(2013)
EGR2_1
0.804 0.899
EGR2
M02886_2.00
Homo sapiens
NNMCGCCCACGCDNN

NNHGCGTGGGCGKNN
SELEX
Jolma et al.(2013)
EGR2_2
0.804 0.899
EGR2
M04439_2.00
Homo sapiens
HMCRCCCACGCNN

NNGCGTGGGYGKD
SELEX
Yin et al.(2017)
EGR2_FL_HT-SELEX
0.804 0.899
EGR2
M08302_2.00
Homo sapiens
CDCCCMCDC

GHGKGGGHG
ChIP-seq
Schmitges et al.(2016)
P11161_1-3.RCADE
0.804 0.899
EGR2
M08884_2.00
Homo sapiens
YYCCDCCCMCDCHYHYHY

RDRDRDGHGKGGGHGGRR
Misc
Kulakovskiy et al.(2013)
EGR2_HUMAN.H11MO.0.A
0.804 0.899
Egr2
M08994_2.00
Mus musculus
BHYCCDCCCMCDCN

NGHGKGGGHGGRDV
Misc
Kulakovskiy et al.(2013)
EGR2_MOUSE.H11MO.0.A
0.804 0.899
Egr2
M09515_2.00
Mus musculus
NMCRCCCACDSN

NSHGTGGGYGKN
Misc
Heinz et al.(2010)
Thymocytes-Egr2_GSE34254
0.804 0.899
EGR2
M10197_2.00
Homo sapiens
MCGCCYACGCAH

DTGCGTRGGCGK
Transfac
Matys et al.(2006)
V$EGR2_01
0.804 0.899
EGR2
M10198_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR2_Q4
0.804 0.899
EGR2
M10199_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR2_Q6
0.804 0.899
EGR2
M04440_2.00
Homo sapiens
NMCGCCCACRCRN

NYGYGTGGGCGKN
SELEX
Yin et al.(2017)
EGR2_FL_Methyl-HT-SELEX
0.804 0.899
EGR2
M00232_2.00
Homo sapiens
NHMCGCCYNN

NNRGGCGKDN
PBM
Barrera et al.(2016)
EGR2_R409W
0.803 0.884
EGR4
M02889_2.00
Homo sapiens
NHMCGCCCACGCAHHN

NDDTGCGTGGGCGKDN
SELEX
Jolma et al.(2013)
EGR4_1
0.796 0.783
EGR4
M02890_2.00
Homo sapiens
NHMCGCCCACGCAHWH

DWDTGCGTGGGCGKDN
SELEX
Jolma et al.(2013)
EGR4_2
0.796 0.783
EGR4
M04461_2.00
Homo sapiens
HMCGCCCACGCAH

DTGCGTGGGCGKD
SELEX
Yin et al.(2017)
EGR4_eDBD_HT-SELEX
0.796 0.783
EGR4
M10216_2.00
Homo sapiens
MCRCCCACGCAW

WTGCGTGGGYGK
Transfac
Matys et al.(2006)
V$NGFIC_01
0.796 0.783
EGR4
M04462_2.00
Homo sapiens
HMCGCCCMCGCRH

DYGCGKGGGCGKD
SELEX
Yin et al.(2017)
EGR4_eDBD_Methyl-HT-SELEX
0.796 0.783
sr
M06072_2.00
Drosophila melanogaster
HVMCGCCCMCVYMH

DKRBGKGGGCGKBD
B1H
Zhu et al.(2011)
sr_SANGER_5_FBgn0003499
0.793 0.884
sr
M06073_2.00
Drosophila melanogaster
NNMCRCCCMCVHNN

NNDBGKGGGYGKNN
B1H
Zhu et al.(2011)
sr_SOLEXA_5_FBgn0003499
0.793 0.884
egrh-1
M00622_2.00
Caenorhabditis elegans
CSCCCMCR

YGKGGGSG
PBM
Narasimhan et al.(2015)
pTH9317
0.781 0.841
EGR2
M00231_2.00
Homo sapiens
MCCMCGCD

HGCGKGGK
PBM
Barrera et al.(2016)
EGR2_R359W
0.758 0.884
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000318057 C2H2 ZF 275 299
ENSP00000318057 C2H2 ZF 305 327
ENSP00000318057 C2H2 ZF 333 355
ENSP00000430310 C2H2 ZF 237 261
ENSP00000430310 C2H2 ZF 267 289
ENSP00000430310 C2H2 ZF 295 317

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

359 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Cebpg Mus musculus ENSMUSG00000056216 D 0.000
CEBPG Homo sapiens ENSG00000153879 D 0.000
ENSTSYG00000002513 Tarsius syrichta ENSTSYG00000002513 I 0.000
CEBPG Vicugna pacos ENSVPAG00000007215 I 0.000
ENSXMAG00000019691 Xiphophorus maculatus ENSXMAG00000019691 I 0.000
HMEL013192 Heliconius melpomene HMEL013192 I 0.000
KGM_20079 Danaus plexippus KGM_20079 I 0.000
TC009211 Tribolium castaneum TC009211 I 0.000
tetur02g05060 Tetranychus urticae tetur02g05060 I 0.000
ASIS008585 Anopheles sinensis ASIS008585 I 0.000
cebpg Takifugu rubripes ENSTRUG00000006448 I 0.000
CEBPG Pan troglodytes ENSPTRG00000010808 I 0.000
Cebpg Rattus norvegicus ENSRNOG00000021144 I 0.000
CEBPG Sorex araneus ENSSARG00000004224 I 0.000
ENSSHAG00000014577 Sarcophilus harrisii ENSSHAG00000014577 I 0.000
CEBPG Sus scrofa ENSSSCG00000002867 I 0.000
ENSSTOG00000007596 Ictidomys tridecemlineatus ENSSTOG00000007596 I 0.000
CEBPG Taeniopygia guttata ENSTGUG00000009474 I 0.000
cebpg Tetraodon nigroviridis ENSTNIG00000001629 I 0.000
tetur11g01620 Tetranychus urticae tetur11g01620 I 0.000
YQE_08773 Dendroctonus ponderosae YQE_08773 I 0.000
Aan_R003393 Calypte anna Aan_R003393 I 0.000
AATE011183 Anopheles atroparvus AATE011183 I 0.000
cebpg Xenopus tropicalis XB-GENE-919758 I 0.000
cebpg.L Xenopus laevis XB-GENE-6077777 I 0.000
LDEC004833 Leptinotarsa decemlineata LDEC004833 I 0.000
estExt_fgenesh2_pg.C_760066 Branchiostoma floridae estExt_fgenesh2_pg.C_760066 I 0.000
estExt_fgenesh2_pg.C_570127 Branchiostoma floridae estExt_fgenesh2_pg.C_570127 I 0.000
Tal_R011314 Tyto alba Tal_R011314 I 0.000
Pvit_06802 Pogona vitticeps Pvit_06802 I 0.000
Ogr04139 Ophisaurus gracilis Ogr04139 I 0.000
Myotis_brandtii_CEBPG_10035215 Myotis brandtii Myotis_brandtii_CEBPG_10035215 I 0.000
Gfo_R009960 Geospiza fortis Gfo_R009960 I 0.000
ENSP00000284000 Macaca fascicularis ENSP00000284000 I 0.000
ENSBTAP00000023345-D1 Bos grunniens ENSBTAP00000023345-D1 I 0.000
Cmyd_10014706 Chelonia mydas Cmyd_10014706 I 0.000
Brh_R009933 Buceros rhinoceros Brh_R009933 I 0.000
Alligator_sinensis_CCG006462.1 Alligator sinensis Alligator_sinensis_CCG006462.1 I 0.000
Afo_R014000 Aptenodytes forsteri Afo_R014000 I 0.000
ENSPSIG00000000373 Pelodiscus sinensis ENSPSIG00000000373 I 0.000
ENSPPYG00000009828 Pongo abelii ENSPPYG00000009828 I 0.000
ENSGALG00000004867 Gallus gallus ENSGALG00000004867 I 0.000
cebpg Gasterosteus aculeatus ENSGACG00000017539 I 0.000
CEBPG Felis catus ENSFCAG00000028096 I 0.000
ENSFALG00000014352 Ficedula albicollis ENSFALG00000014352 I 0.000
CEBPG Echinops telfairi ENSETEG00000017071 I 0.000
CEBPG Erinaceus europaeus ENSEEUG00000012797 I 0.000
CEBPG Equus caballus ENSECAG00000004879 I 0.000
CEBPG Dasypus novemcinctus ENSDNOG00000003950 I 0.000
cebpg Danio rerio ENSDARG00000036073 I 0.000
ENSCSAG00000018517 Chlorocebus sabaeus ENSCSAG00000018517 I 0.000
ENSCPOG00000014835 Cavia porcellus ENSCPOG00000014835 I 0.000
CEBPG Callithrix jacchus ENSCJAG00000035363 I 0.000
CEBPG Canis familiaris ENSCAFG00000007405 I 0.000
CEBPG Bos taurus ENSBTAG00000017560 I 0.000
ENSAPLG00000000568 Anas platyrhynchos ENSAPLG00000000568 I 0.000
ENSAMXG00000026123 Astyanax mexicanus ENSAMXG00000026123 I 0.000
ENSAMEG00000018841 Ailuropoda melanoleuca ENSAMEG00000018841 I 0.000
CEBPG Gorilla gorilla ENSGGOG00000012138 I 0.000
ENSLACG00000005088 Latimeria chalumnae ENSLACG00000005088 I 0.000
ENSPANG00000016413 Papio anubis ENSPANG00000016413 I 0.000
cebpg Oryzias latipes ENSORLG00000018652 I 0.000
CEBPG Ochotona princeps ENSOPRG00000012139 I 0.000
ENSONIG00000020606 Oreochromis niloticus ENSONIG00000020606 I 0.000
CEBPG Otolemur garnettii ENSOGAG00000010436 I 0.000
CEBPG Oryctolagus cuniculus ENSOCUG00000017036 I 0.000
ENSOARG00000011183 Ovis aries ENSOARG00000011183 I 0.000
CEBPG Ornithorhynchus anatinus ENSOANG00000008143 I 0.000
ENSNLEG00000018562 Nomascus leucogenys ENSNLEG00000018562 I 0.000
ENSMPUG00000018937 Mustela putorius furo ENSMPUG00000018937 I 0.000
CEBPG Monodelphis domestica ENSMODG00000023494 I 0.000
CEBPG Macaca mulatta ENSMMUG00000006127 I 0.000
CEBPG Myotis lucifugus ENSMLUG00000005181 I 0.000
ENSMICG00000013426 Microcebus murinus ENSMICG00000013426 I 0.000
CEBPG Meleagris gallopavo ENSMGAG00000015603 I 0.000
ENSLOCG00000017587 Lepisosteus oculatus ENSLOCG00000017587 I 0.000
CEBPG Loxodonta africana ENSLAFG00000017998 I 0.000
CEBPG Anolis carolinensis ENSACAG00000013617 I 0.000