ZBTB42 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000179627 T095179_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZBTB42
M08351_2.00
Homo sapiens
MRCAKCTGS

SCAGMTGYK
ChIP-seq
Schmitges et al.(2016)
B2RXF5_2-4.RCADE
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000409107 C2H2 ZF 294 316
ENSP00000409107 C2H2 ZF 335 356
ENSP00000409107 C2H2 ZF 362 384
ENSP00000409107 C2H2 ZF 390 413
ENSP00000450673 C2H2 ZF 294 316
ENSP00000450673 C2H2 ZF 335 356
ENSP00000450673 C2H2 ZF 362 384
ENSP00000450673 C2H2 ZF 390 413

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

23 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ZBTB42 Pan troglodytes ENSPTRG00000040287 I 0.827
ENSCSAG00000019588 Chlorocebus sabaeus ENSCSAG00000019588 I 0.827
ENSP00000409107 Macaca fascicularis ENSP00000409107 I 0.825
ENSAMEG00000007755 Ailuropoda melanoleuca ENSAMEG00000007755 I 0.799
ZBTB42 Monodelphis domestica ENSMODG00000013701 I 0.787
ENSSHAG00000008534 Sarcophilus harrisii ENSSHAG00000008534 I 0.787
znf238.2 Xenopus tropicalis XB-GENE-1219066 I 0.782
Pvit_02527 Pogona vitticeps Pvit_02527 I 0.776
zbtb42 Gasterosteus aculeatus ENSGACG00000006297 I 0.775
ZBTB42 Gallus gallus ENSGALG00000023025 I 0.773
ZBTB42 Meleagris gallopavo ENSMGAG00000015389 I 0.773
Alligator_sinensis_CCG020881.1 Alligator sinensis Alligator_sinensis_CCG020881.1 I 0.773
Ogr11588 Ophisaurus gracilis Ogr11588 I 0.772
ENSXMAG00000006703 Xiphophorus maculatus ENSXMAG00000006703 I 0.770
zbtb42 Takifugu rubripes ENSTRUG00000013592 I 0.770
zbtb42 Oryzias latipes ENSORLG00000017008 I 0.770
ENSLOCG00000012759 Lepisosteus oculatus ENSLOCG00000012759 I 0.770
ENSONIG00000012149 Oreochromis niloticus ENSONIG00000012149 I 0.770
zbtb42 Tetraodon nigroviridis ENSTNIG00000000917 I 0.770
ENSPFOG00000010298 Poecilia formosa ENSPFOG00000010298 I 0.770
zbtb42 Danio rerio ENSDARG00000102761 I 0.769
ZBTB42 Anolis carolinensis ENSACAG00000011451 I 0.760