MTF1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000188786 T095271_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MTF1
M02922_2.00
Homo sapiens
GTGCCGTGTGCAAA

TTTGCACACGGCAC
SELEX
Jolma et al.(2013)
MTF1_1
(Direct) (Direct)
MTF1
M04617_2.00
Homo sapiens
NDNDYCGTGTGCAAARN

NYTTTGCACACGRHNHN
SELEX
Yin et al.(2017)
MTF1_eDBD_HT-SELEX
(Direct) (Direct)
MTF1
M04618_2.00
Homo sapiens
NRNRCCGTGTGCAAARV

BYTTTGCACACGGYNYN
SELEX
Yin et al.(2017)
MTF1_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
MTF1
M08942_2.00
Homo sapiens
MGKVHCGTGYGCADMDB

VHKHTGCRCACGDBMCK
Misc
Kulakovskiy et al.(2013)
MTF1_HUMAN.H11MO.0.C
(Direct) (Direct)
MTF1
M10308_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MTF1_01
(Direct) (Direct)
MTF1
M10309_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MTF1_02
(Direct) (Direct)
MTF1
M10310_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MTF1_Q4
(Direct) (Direct)
MTF1
M10311_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MTF1_Q5
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mtf1
M00136_2.00
Mus musculus
CGTGYGCAM

KTGCRCACG
PBM
Badis et al.(2009)
Mtf1_2377
0.827 1.000
Mtf1
M08981_2.00
Mus musculus
MGKVHCGTGYGCADMDB

VHKHTGCRCACGDBMCK
Misc
Kulakovskiy et al.(2013)
MTF1_MOUSE.H11MO.0.C
0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000362127 C2H2 ZF 140 164
ENSP00000362127 C2H2 ZF 170 194
ENSP00000362127 C2H2 ZF 200 224
ENSP00000362127 C2H2 ZF 229 253
ENSP00000362127 C2H2 ZF 259 283
ENSP00000362127 C2H2 ZF 289 313

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

64 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSNLEG00000011682 Nomascus leucogenys ENSNLEG00000011682 I 0.827
ENSTSYG00000005589 Tarsius syrichta ENSTSYG00000005589 I 0.827
ENSOARG00000019896 Ovis aries ENSOARG00000019896 I 0.827
Mtf1 Mus musculus ENSMUSG00000028890 D 0.827
ENSMPUG00000014538 Mustela putorius furo ENSMPUG00000014538 I 0.827
MTF1 Myotis lucifugus ENSMLUG00000000963 I 0.827
MTF1 Macaca mulatta ENSMMUG00000023275 I 0.827
MTF1 Oryctolagus cuniculus ENSOCUG00000005389 I 0.827
ENSPANG00000016211 Papio anubis ENSPANG00000016211 I 0.827
Mtf1 Rattus norvegicus ENSRNOG00000025724 I 0.827
LOC100909856 Rattus norvegicus ENSRNOG00000050240 I 0.827
MTF1 Pteropus vampyrus ENSPVAG00000010152 I 0.827
MTF1 Pan troglodytes ENSPTRG00000022932 I 0.827
ENSSTOG00000025276 Ictidomys tridecemlineatus ENSSTOG00000025276 I 0.827
ENSPPYG00000001521 Pongo abelii ENSPPYG00000001521 I 0.827
MTF1 Tursiops truncatus ENSTTRG00000013535 I 0.827
MTF1 Microcebus murinus ENSMICG00000011969 I 0.827
MTF1 Callithrix jacchus ENSCJAG00000002097 I 0.827
MTF1 Cavia porcellus ENSCPOG00000014657 I 0.827
ENSCSAG00000001118 Chlorocebus sabaeus ENSCSAG00000001118 I 0.827
MTF1 Canis familiaris ENSCAFG00000003247 I 0.827
MTF1 Bos taurus ENSBTAG00000006511 I 0.827
ENSAMEG00000001186 Ailuropoda melanoleuca ENSAMEG00000001186 I 0.827
ENSP00000362127 Macaca fascicularis ENSP00000362127 I 0.827
ENSBTAP00000008535-D1 Bos grunniens ENSBTAP00000008535-D1 I 0.827
MTF1 Equus caballus ENSECAG00000017235 I 0.827
MTF1 Dasypus novemcinctus ENSDNOG00000009118 I 0.827
Myotis_brandtii_MTF1_10028927 Myotis brandtii Myotis_brandtii_MTF1_10028927 I 0.827
MTF1 Gorilla gorilla ENSGGOG00000007624 I 0.827
MTF1 Echinops telfairi ENSETEG00000003045 I 0.827
MTF1 Felis catus ENSFCAG00000011020 I 0.827
MTF1 Otolemur garnettii ENSOGAG00000000872 I 0.825
Alligator_sinensis_CCG001426.1 Alligator sinensis Alligator_sinensis_CCG001426.1 I 0.825
Cmyd_10015325 Chelonia mydas Cmyd_10015325 I 0.821
ENSSHAG00000014007 Sarcophilus harrisii ENSSHAG00000014007 I 0.821
Ogr09934 Ophisaurus gracilis Ogr09934 I 0.821
MTF1 Anolis carolinensis ENSACAG00000017181 I 0.821
MTF1 Monodelphis domestica ENSMODG00000017745 I 0.821
Pvit_17763 Pogona vitticeps Pvit_17763 I 0.821
ENSPSIG00000005687 Pelodiscus sinensis ENSPSIG00000005687 I 0.819
ENSLOCG00000003310 Lepisosteus oculatus ENSLOCG00000003310 I 0.818
MTF1 Ornithorhynchus anatinus ENSOANG00000002047 I 0.817
ENSAMXG00000001644 Astyanax mexicanus ENSAMXG00000001644 I 0.815
Tal_R009432 Tyto alba Tal_R009432 I 0.809
Afo_R013895 Aptenodytes forsteri Afo_R013895 I 0.809
Brh_R010359 Buceros rhinoceros Brh_R010359 I 0.809
ENSFALG00000000973 Ficedula albicollis ENSFALG00000000973 I 0.809
ENSAPLG00000016056 Anas platyrhynchos ENSAPLG00000016056 I 0.809
Aan_R005906 Calypte anna Aan_R005906 I 0.809
MTF1 Gallus gallus ENSGALG00000001639 I 0.809
MTF1 Oryzias latipes ENSORLG00000014411 I 0.809
MTF1 Taeniopygia guttata ENSTGUG00000001500 I 0.809
Gfo_R001683 Geospiza fortis Gfo_R001683 I 0.809
MTF1 Meleagris gallopavo ENSMGAG00000003052 I 0.809
ENSXMAG00000014614 Xiphophorus maculatus ENSXMAG00000014614 I 0.809
ENSPFOG00000013962 Poecilia formosa ENSPFOG00000013962 I 0.809
ENSONIG00000016218 Oreochromis niloticus ENSONIG00000016218 I 0.807
MTF1 Gasterosteus aculeatus ENSGACG00000013875 I 0.807
ENSGMOG00000015592 Gadus morhua ENSGMOG00000015592 I 0.805
mtf1.L Xenopus laevis XB-GENE-979131 I 0.790
mtf1 Xenopus tropicalis XB-GENE-979128 I 0.790
tetur01g09970 Tetranychus urticae tetur01g09970 I 0.780
Sakowv30031703m.g Saccoglossus kowalevskii Sakowv30031703m.g I 0.771
MTF1 Takifugu rubripes ENSTRUG00000005297 I 0.761