ZNF124 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000196418 T095302_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a protein with an amino-terminal KRAB-A box and multiple repeated Kruppel-type (C2H2) zinc finger motifs at its carboxy terminus. The encoded protein may function as a transcription factor. Expression of this gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF124
M07702_2.00
Homo sapiens
CTTYTYCCYTBS

SVARGGRARAAG
ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF124.RCADE.OriginalMapping
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000340749 C2H2 ZF 88 110
ENSP00000340749 C2H2 ZF 116 138
ENSP00000340749 C2H2 ZF 144 166
ENSP00000340749 C2H2 ZF 172 194
ENSP00000340749 C2H2 ZF 200 222
ENSP00000340749 C2H2 ZF 228 250
ENSP00000340749 C2H2 ZF 256 278
ENSP00000440365 C2H2 ZF 122 144
ENSP00000440365 C2H2 ZF 150 172
ENSP00000440365 C2H2 ZF 178 200
ENSP00000440365 C2H2 ZF 206 228
ENSP00000440365 C2H2 ZF 234 256
ENSP00000440365 C2H2 ZF 262 284
ENSP00000440365 C2H2 ZF 290 312
ENSP00000440365 C2H2 ZF 318 340

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

6 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ZNF124 Gorilla gorilla ENSGGOG00000013838 I 0.827
ZNF124 Pan troglodytes ENSPTRG00000023216 N 0.827
ENSPPYG00000000039 Pongo abelii ENSPPYG00000000039 N 0.825
ZNF124 Macaca mulatta ENSMMUG00000004566 I 0.823
ENSNLEG00000004257 Nomascus leucogenys ENSNLEG00000004257 I 0.813
ENSP00000355455 Macaca fascicularis ENSP00000355455 I 0.797