ZNF136 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000196646 T095310_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) A-box domain at its N-terminus, followed by fourteen contiguous C2H2 zinc finger domains and a degenerate zinc finger. The KRAB A-box showed weak transcriptional repressor activity in a reporter gene assay. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZNF136
M07708_2.00		 Homo sapiens
DYTTTGCTGGRTAYAGWATTCTWGGTT
AACCWAGAATWCTRTAYCCAGCAAARH		 ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF136.RCADE.OriginalMapping		 (Direct) (Direct)
ZNF136
M08265_2.00		 Homo sapiens
TCATTTYTGAAGGAYADYTTT
AAARHTRTCCTTCARAAATGA		 ChIP-seq
Najafabadi et al.(2015b)
ZNF136		 (Direct) (Direct)
ZNF136
M08374_2.00		 Homo sapiens
CTGGRTAYAGWATTCTTG
CAAGAATWCTRTAYCCAG		 ChIP-seq
Schmitges et al.(2016)
P52737.MEME		 (Direct) (Direct)
ZNF136
M08946_2.00		 Homo sapiens
TGCTGGRTAYAGWATTCTKGGYTG
CARCCMAGAATWCTRTAYCCAGCA		 Misc
Kulakovskiy et al.(2013)
ZN136_HUMAN.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000344162 C2H2 ZF 168 190
ENSP00000344162 C2H2 ZF 196 218
ENSP00000344162 C2H2 ZF 224 246
ENSP00000344162 C2H2 ZF 252 274
ENSP00000344162 C2H2 ZF 280 302
ENSP00000344162 C2H2 ZF 308 330
ENSP00000344162 C2H2 ZF 336 358
ENSP00000344162 C2H2 ZF 364 386
ENSP00000344162 C2H2 ZF 392 414
ENSP00000344162 C2H2 ZF 420 442
ENSP00000344162 C2H2 ZF 448 470
ENSP00000344162 C2H2 ZF 476 498
ENSP00000344162 C2H2 ZF 504 526

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

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8 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action