YY2 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000230797 T095455_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
YY2
M02926_2.00		 Homo sapiens
NNYCGCCATYD
HRATGGCGRNN		 SELEX
Jolma et al.(2013)
YY2_1		 (Direct) (Direct)
YY2
M02927_2.00		 Homo sapiens
NCCGCCATNHH
DDNATGGCGGN		 SELEX
Jolma et al.(2013)
YY2_2		 (Direct) (Direct)
YY2
M02928_2.00		 Homo sapiens
NMWTKCCGCCAT
ATGGCGGMAWKN		 SELEX
Jolma et al.(2013)
YY2_3		 (Direct) (Direct)
YY2
M04647_2.00		 Homo sapiens
NDCCGCCATTTTGD
HCAAAATGGCGGHN		 SELEX
Yin et al.(2017)
YY2_FL_HT-SELEX		 (Direct) (Direct)
YY2
M04648_2.00		 Homo sapiens
DKCSGCCATTTTGD
HCAAAATGGCSGMH		 SELEX
Yin et al.(2017)
YY2_FL_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000389381 C2H2 ZF 254 278
ENSP00000389381 C2H2 ZF 283 305
ENSP00000389381 C2H2 ZF 311 335
ENSP00000389381 C2H2 ZF 341 365

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

2 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action