CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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YY2
(
Homo sapiens
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSG00000230797
T095455_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
YY2
M02926_2.00
Homo sapiens
NNYCGCCATYD
HRATGGCGRNN
SELEX
Jolma et al.(2013)
YY2_1
(Direct)
(Direct)
YY2
M02927_2.00
Homo sapiens
NCCGCCATNHH
DDNATGGCGGN
SELEX
Jolma et al.(2013)
YY2_2
(Direct)
(Direct)
YY2
M02928_2.00
Homo sapiens
NMWTKCCGCCAT
ATGGCGGMAWKN
SELEX
Jolma et al.(2013)
YY2_3
(Direct)
(Direct)
YY2
M04647_2.00
Homo sapiens
NDCCGCCATTTTGD
HCAAAATGGCGGHN
SELEX
Yin et al.(2017)
YY2_FL_HT-SELEX
(Direct)
(Direct)
YY2
M04648_2.00
Homo sapiens
DKCSGCCATTTTGD
HCAAAATGGCSGMH
SELEX
Yin et al.(2017)
YY2_FL_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000389381
C2H2 ZF
254
278
VPCSYSGCEKMFRDYAAMRKHLHIH
ENSP00000389381
C2H2 ZF
283
305
HVCAECGKAFLESSKLRRHQLVH
ENSP00000389381
C2H2 ZF
311
335
FQCTFEGCGKRFSLDFNLRTHLRIH
ENSP00000389381
C2H2 ZF
341
365
FVCPFDVCNRKFAQSTNLKTHILTH
Links
Other
C2H2 ZF
family TFs
Other
Homo sapiens
TFs
2 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy