SALL3 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000256463 T095478_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000439975 C2H2 ZF 287 309
ENSP00000439975 C2H2 ZF 315 337
ENSP00000439975 C2H2 ZF 547 568
ENSP00000439975 C2H2 ZF 574 596
ENSP00000439975 C2H2 ZF 606 628
ENSP00000439975 C2H2 ZF 908 930
ENSP00000439975 C2H2 ZF 936 958
ENSP00000441823 C2H2 ZF 420 442
ENSP00000441823 C2H2 ZF 448 470
ENSP00000441823 C2H2 ZF 680 701
ENSP00000441823 C2H2 ZF 707 729
ENSP00000441823 C2H2 ZF 739 761
ENSP00000441823 C2H2 ZF 977 999
ENSP00000441823 C2H2 ZF 1005 1027
ENSP00000441823 C2H2 ZF 1113 1135
ENSP00000441823 C2H2 ZF 1141 1163
ENSP00000458360 C2H2 ZF 420 442
ENSP00000458360 C2H2 ZF 448 470
ENSP00000458360 C2H2 ZF 680 701
ENSP00000458360 C2H2 ZF 707 729
ENSP00000458360 C2H2 ZF 739 761
ENSP00000458360 C2H2 ZF 1041 1063
ENSP00000458360 C2H2 ZF 1069 1091
ENSP00000461451 C2H2 ZF 106 128
ENSP00000461451 C2H2 ZF 134 150
ENSP00000481352 C2H2 ZF 152 174
ENSP00000481352 C2H2 ZF 180 202
ENSP00000481352 C2H2 ZF 412 433
ENSP00000481352 C2H2 ZF 439 461
ENSP00000481352 C2H2 ZF 471 493
ENSP00000481352 C2H2 ZF 773 795
ENSP00000481352 C2H2 ZF 801 823

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

71 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Afo_R009325 Aptenodytes forsteri Afo_R009325 N 0.822
Alligator_sinensis_CCG003694.1 Alligator sinensis Alligator_sinensis_CCG003694.1 N 0.822
Brh_R007854 Buceros rhinoceros Brh_R007854 N 0.822
Cmyd_10010411 Chelonia mydas Cmyd_10010411 N 0.817
SALL3 Anolis carolinensis ENSACAG00000000478 N 0.827
ENSAMEG00000010206 Ailuropoda melanoleuca ENSAMEG00000010206 N 0.825
ENSAPLG00000013214 Anas platyrhynchos ENSAPLG00000013214 N 0.827
SALL3 Canis familiaris ENSCAFG00000000013 N 0.825
SALL3 Callithrix jacchus ENSCJAG00000007332 N 0.827
SALL3 Cavia porcellus ENSCPOG00000008546 N 0.827
ENSCSAG00000018244 Chlorocebus sabaeus ENSCSAG00000018244 N 0.827
sall3b Danio rerio ENSDARG00000057586 N 0.816
sall3a Danio rerio ENSDARG00000079613 N 0.821
SALL3 Dasypus novemcinctus ENSDNOG00000025483 N 0.814
Sall3 Dipodomys ordii ENSDORG00000002702 N 0.791
SALL3 Equus caballus ENSECAG00000015414 N 0.827
ENSFALG00000013343 Ficedula albicollis ENSFALG00000013343 N 0.827
sall3a Gasterosteus aculeatus ENSGACG00000005503 N 0.815
sall1a Gasterosteus aculeatus ENSGACG00000016702 N 0.756
ENSGALG00000012657 Gallus gallus ENSGALG00000012657 N 0.827
SALL3 Gorilla gorilla ENSGGOG00000008127 N 0.827
ENSGMOG00000006649 Gadus morhua ENSGMOG00000006649 N 0.821
SALL3 Loxodonta africana ENSLAFG00000013521 N 0.818
ENSLOCG00000007283 Lepisosteus oculatus ENSLOCG00000007283 N 0.757
ENSLOCG00000007831 Lepisosteus oculatus ENSLOCG00000007831 N 0.823
SALL3 Meleagris gallopavo ENSMGAG00000002297 N 0.827
SALL3 Myotis lucifugus ENSMLUG00000010582 N 0.803
SALL3 Macaca mulatta ENSMMUG00000000286 N 0.827
SALL3 Monodelphis domestica ENSMODG00000012231 N 0.827
ENSMPUG00000016646 Mustela putorius furo ENSMPUG00000016646 N 0.825
Sall3 Mus musculus ENSMUSG00000024565 N 0.827
ENSNLEG00000008217 Nomascus leucogenys ENSNLEG00000008217 N 0.795
SALL1 Ornithorhynchus anatinus ENSOANG00000013399 N 0.799
ENSOARG00000004353 Ovis aries ENSOARG00000004353 N 0.801
ENSOARG00000017583 Ovis aries ENSOARG00000017583 N 0.759
SALL3 Oryctolagus cuniculus ENSOCUG00000029398 N 0.825
SALL1 Otolemur garnettii ENSOGAG00000027316 N 0.764
SALL3 Otolemur garnettii ENSOGAG00000031681 N 0.826
ENSONIG00000002831 Oreochromis niloticus ENSONIG00000002831 N 0.763
ENSONIG00000007305 Oreochromis niloticus ENSONIG00000007305 N 0.816
sall1a Oryzias latipes ENSORLG00000013827 N 0.756
sall3a Oryzias latipes ENSORLG00000020718 N 0.816
ENSP00000299466-D1 Bos grunniens ENSP00000299466-D1 N 0.811
ENSPANG00000006485 Papio anubis ENSPANG00000006485 N 0.827
SALL3 Procavia capensis ENSPCAG00000006522 N 0.815
ENSPFOG00000015799 Poecilia formosa ENSPFOG00000015799 N 0.756
ENSPFOG00000019127 Poecilia formosa ENSPFOG00000019127 N 0.815
ENSPPYG00000009253 Pongo abelii ENSPPYG00000009253 N 0.827
ENSPSIG00000008556 Pelodiscus sinensis ENSPSIG00000008556 N 0.827
SALL3 Pan troglodytes ENSPTRG00000010126 N 0.827
Sall1 Rattus norvegicus ENSRNOG00000013907 N 0.764
Sall3 Rattus norvegicus ENSRNOG00000026116 N 0.825
ENSSHAG00000015872 Sarcophilus harrisii ENSSHAG00000015872 N 0.827
SALL3 Sus scrofa ENSSSCG00000004858 N 0.810
ENSSTOG00000004145 Ictidomys tridecemlineatus ENSSTOG00000004145 N 0.827
sall1a Tetraodon nigroviridis ENSTNIG00000004257 N 0.763
sall1a Takifugu rubripes ENSTRUG00000008950 N 0.791
SALL3 Tursiops truncatus ENSTTRG00000004958 N 0.826
ENSXMAG00000009081 Xiphophorus maculatus ENSXMAG00000009081 N 0.809
ENSXMAG00000016273 Xiphophorus maculatus ENSXMAG00000016273 N 0.756
Gfo_R000617 Geospiza fortis Gfo_R000617 N 0.822
Myotis_brandtii_Sall3_10034211 Myotis brandtii Myotis_brandtii_Sall3_10034211 N 0.803
Ogr15828 Ophisaurus gracilis Ogr15828 N 0.822
Pvit_05136 Pogona vitticeps Pvit_05136 N 0.827
Tal_R008175 Tyto alba Tal_R008175 N 0.822
sall1 Xenopus tropicalis XB-GENE-491393 N 0.764
sall1.L Xenopus laevis XB-GENE-866060 N 0.762
XP_002936493 Xenopus tropicalis XP_002936493 N 0.816
XP_002936494 Xenopus tropicalis XP_002936494 N 0.816
XP_002936495 Xenopus tropicalis XP_002936495 N 0.816