ZNF224 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000267680 T095493_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF224
M07778_2.00
Homo sapiens
YWHVMYYNSRDKNMAYWBSAHTYVMTKVSM

RYKKDAKSBMAKBRADTSVWRTKNMHYSNR
ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF224.RCADE.ReprocessedData
(Direct) (Direct)
ZNF224
M08399_2.00
Homo sapiens
WMCYYNKGDGYHMHRKGRMTY

RAKYCMYDKDRCHCMNRRGKW
ChIP-seq
Schmitges et al.(2016)
Q9NZL3_5-11.RCADE
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000337368 C2H2 ZF 176 198
ENSP00000337368 C2H2 ZF 204 226
ENSP00000337368 C2H2 ZF 232 254
ENSP00000337368 C2H2 ZF 260 282
ENSP00000337368 C2H2 ZF 288 310
ENSP00000337368 C2H2 ZF 316 338
ENSP00000337368 C2H2 ZF 344 366
ENSP00000337368 C2H2 ZF 372 394
ENSP00000337368 C2H2 ZF 400 422
ENSP00000337368 C2H2 ZF 428 450
ENSP00000337368 C2H2 ZF 456 478
ENSP00000337368 C2H2 ZF 484 506
ENSP00000337368 C2H2 ZF 512 534
ENSP00000337368 C2H2 ZF 540 562
ENSP00000337368 C2H2 ZF 568 590
ENSP00000337368 C2H2 ZF 596 618
ENSP00000337368 C2H2 ZF 652 674
ENSP00000337368 C2H2 ZF 680 702

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

7 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ZNF224 Pan troglodytes ENSPTRG00000011105 I 0.827
ENSPPYG00000029591 Pongo abelii ENSPPYG00000029591 I 0.824
ENSCSAG00000003342 Chlorocebus sabaeus ENSCSAG00000003342 I 0.814
ENSNLEG00000001866 Nomascus leucogenys ENSNLEG00000001866 I 0.813
ENSMMUP00000031578 Macaca fascicularis ENSMMUP00000031578 I 0.799
ENSMMUG00000021472 Macaca mulatta ENSMMUG00000021472 I 0.799
ZNF226 Callithrix jacchus ENSCJAG00000013321 I 0.782