CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Gli3
(
Mus musculus
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSMUSG00000021318
T101021_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative thymic T cell selection; regulation of alpha-beta T cell differentiation; and thymocyte apoptotic process. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of cell differentiation. Located in axoneme and nuclear speck. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Gli3
M01022_2.00
Mus musculus
NGACCACCCNN
NNGGGTGGTCN
PBM
Peterson et al.(2012)
Gli3
(Direct)
(Direct)
Gli3
M08023_2.00
Mus musculus
RGVCCACCCAS
STGGGTGGBCY
ChIP-seq
Chen et al.(2011)
GSE11062_Gli3
(Direct)
(Direct)
Gli3
M09512_2.00
Mus musculus
RGACCACCCASR
YSTGGGTGGTCY
Misc
Heinz et al.(2010)
Limb-GLI3_GSE11077
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
GLI3
M04416_2.00
Homo sapiens
VGACCACCCACVNHG
CDNBGTGGGTGGTCB
SELEX
Yin et al.(2017)
GLI3_eDBD_HT-SELEX
0.781
0.983
GLI3
M02642_2.00
Homo sapiens
GACCACCCANK
MNTGGGTGGTC
SELEX
Hallikas et al.(2006)
GLI3
0.781
0.983
GLI3
M08875_2.00
Homo sapiens
VRACCACCCAV
BTGGGTGGTYB
Misc
Kulakovskiy et al.(2013)
GLI3_HUMAN.H11MO.0.B
0.781
0.983
GLI3
M10167_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GLI3_01
0.781
0.983
GLI3
M10168_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GLI3_Q5_01
0.781
0.983
GLI3
M04417_2.00
Homo sapiens
CWHBGTGGGTGGTCY
RGACCACCCACVDWG
SELEX
Yin et al.(2017)
GLI3_eDBD_Methyl-HT-SELEX
0.781
0.983
Gli2
M01024_2.00
Mus musculus
NGACCACCYN
NRGGTGGTCN
PBM
Peterson et al.(2012)
Gli2
0.761
0.930
GLI2
M02875_2.00
Homo sapiens
GMCCACMCANVNHB
VDNBNTGKGTGGKC
SELEX
Jolma et al.(2013)
GLI2_1
0.761
0.930
GLI2
M02876_2.00
Homo sapiens
GCGACCACVCWR
YWGBGTGGTCGC
SELEX
Jolma et al.(2013)
GLI2_2
0.761
0.930
GLI2
M02732_2.00
Homo sapiens
GACCACMCAN
NTGKGTGGTC
SELEX
Jolma et al.(2010)
GLI2_monomer
0.761
0.930
GLI2
M04402_2.00
Homo sapiens
VGACCACCCACVDHG
CDHBGTGGGTGGTCB
SELEX
Yin et al.(2017)
GLI2_eDBD_HT-SELEX
0.761
0.930
GLI2
M02641_2.00
Homo sapiens
GACCACCCAHG
CDTGGGTGGTC
SELEX
Hallikas et al.(2006)
GLI2
0.761
0.930
GLI2
M10114_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GLI2_Q3
0.761
0.930
GLI2
M10115_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GLI2_Q6
0.761
0.930
GLI2
M04403_2.00
Homo sapiens
RGACCACCCACVWWG
CWWBGTGGGTGGTCY
SELEX
Yin et al.(2017)
GLI2_eDBD_Methyl-HT-SELEX
0.761
0.930
For this family, TFs with SR scores >
0.755
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M01022_2.00
C2H2 ZF
16
41
TNCHWEGCTREFDTQDQLVHHINNDH
M01022_2.00
C2H2 ZF
49
76
FVCRWLDCSREQKPFKAQYMLVVHMRRH
M01022_2.00
C2H2 ZF
82
106
HKCTFEGCTKAYSRLENLKTHLRSH
M01022_2.00
C2H2 ZF
112
137
YVCEHEGCNKAFSNASDRAKHQNRTH
M01022_2.00
C2H2 ZF
143
168
YVCKIPGCTKRYTDPSSLRKHVKTVH
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000106137
C2H2 ZF
480
505
TNCHWEGCTREFDTQDQLVHHINNDH
ENSMUSP00000106137
C2H2 ZF
513
540
FVCRWLDCSREQKPFKAQYMLVVHMRRH
ENSMUSP00000106137
C2H2 ZF
546
570
HKCTFEGCTKAYSRLENLKTHLRSH
ENSMUSP00000106137
C2H2 ZF
576
601
YVCEHEGCNKAFSNASDRAKHQNRTH
ENSMUSP00000106137
C2H2 ZF
607
632
YVCKIPGCTKRYTDPSSLRKHVKTVH
ENSMUSP00000115989
C2H2 ZF
480
505
TNCHWEGCTREFDTQDQLVHHINNDH
ENSMUSP00000115989
C2H2 ZF
513
540
FVCRWLDCSREQKPFKAQYMLVVHMRRH
ENSMUSP00000115989
C2H2 ZF
546
570
HKCTFEGCTKAYSRLENLKTHLRSH
ENSMUSP00000115989
C2H2 ZF
576
596
YVCEHEGCNKAFSNASDRAKH
Links
Other
C2H2 ZF
family TFs
Other
Mus musculus
TFs
139 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy