Gli3 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000021318 T101021_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative thymic T cell selection; regulation of alpha-beta T cell differentiation; and thymocyte apoptotic process. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of cell differentiation. Located in axoneme and nuclear speck. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Gli3
M01022_2.00		 Mus musculus
NGACCACCCNN
NNGGGTGGTCN		 PBM
Peterson et al.(2012)
Gli3		 (Direct) (Direct)
Gli3
M08023_2.00		 Mus musculus
RGVCCACCCAS
STGGGTGGBCY		 ChIP-seq
Chen et al.(2011)
GSE11062_Gli3		 (Direct) (Direct)
Gli3
M09512_2.00		 Mus musculus
RGACCACCCASR
YSTGGGTGGTCY		 Misc
Heinz et al.(2010)
Limb-GLI3_GSE11077		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
GLI3
M04416_2.00 		Homo sapiens
VGACCACCCACVNHG
CDNBGTGGGTGGTCB		 SELEX
Yin et al.(2017)
GLI3_eDBD_HT-SELEX 		0.781 0.983
GLI3
M02642_2.00 		Homo sapiens
GACCACCCANK
MNTGGGTGGTC		 SELEX
Hallikas et al.(2006)
GLI3 		0.781 0.983
GLI3
M08875_2.00 		Homo sapiens
VRACCACCCAV
BTGGGTGGTYB		 Misc
Kulakovskiy et al.(2013)
GLI3_HUMAN.H11MO.0.B 		0.781 0.983
GLI3
M10167_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$GLI3_01 		0.781 0.983
GLI3
M10168_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$GLI3_Q5_01 		0.781 0.983
GLI3
M04417_2.00 		Homo sapiens
CWHBGTGGGTGGTCY
RGACCACCCACVDWG		 SELEX
Yin et al.(2017)
GLI3_eDBD_Methyl-HT-SELEX 		0.781 0.983
Gli2
M01024_2.00 		Mus musculus
NGACCACCYN
NRGGTGGTCN		 PBM
Peterson et al.(2012)
Gli2 		0.761 0.930
GLI2
M02875_2.00 		Homo sapiens
GMCCACMCANVNHB
VDNBNTGKGTGGKC		 SELEX
Jolma et al.(2013)
GLI2_1 		0.761 0.930
GLI2
M02876_2.00 		Homo sapiens
GCGACCACVCWR
YWGBGTGGTCGC		 SELEX
Jolma et al.(2013)
GLI2_2 		0.761 0.930
GLI2
M02732_2.00 		Homo sapiens
GACCACMCAN
NTGKGTGGTC		 SELEX
Jolma et al.(2010)
GLI2_monomer 		0.761 0.930
GLI2
M04402_2.00 		Homo sapiens
VGACCACCCACVDHG
CDHBGTGGGTGGTCB		 SELEX
Yin et al.(2017)
GLI2_eDBD_HT-SELEX 		0.761 0.930
GLI2
M02641_2.00 		Homo sapiens
GACCACCCAHG
CDTGGGTGGTC		 SELEX
Hallikas et al.(2006)
GLI2 		0.761 0.930
GLI2
M10114_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$GLI2_Q3 		0.761 0.930
GLI2
M10115_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$GLI2_Q6 		0.761 0.930
GLI2
M04403_2.00 		Homo sapiens
RGACCACCCACVWWG
CWWBGTGGGTGGTCY		 SELEX
Yin et al.(2017)
GLI2_eDBD_Methyl-HT-SELEX 		0.761 0.930
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01022_2.00 C2H2 ZF 16 41
M01022_2.00 C2H2 ZF 49 76
M01022_2.00 C2H2 ZF 82 106
M01022_2.00 C2H2 ZF 112 137
M01022_2.00 C2H2 ZF 143 168

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000106137 C2H2 ZF 480 505
ENSMUSP00000106137 C2H2 ZF 513 540
ENSMUSP00000106137 C2H2 ZF 546 570
ENSMUSP00000106137 C2H2 ZF 576 601
ENSMUSP00000106137 C2H2 ZF 607 632
ENSMUSP00000115989 C2H2 ZF 480 505
ENSMUSP00000115989 C2H2 ZF 513 540
ENSMUSP00000115989 C2H2 ZF 546 570
ENSMUSP00000115989 C2H2 ZF 576 596

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

Invalid Input OrderBy

139 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action