Sall4 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000027547 T101066_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene belongs to the spalt family of zinc finger transcription factors. In mouse, functions for this gene have been described in many embryonic developmental processes, including brain, heart, and limb development. In addition, this gene is an important pluripotency factor that is required for stem cell maintenance. Homozygous mutant mice display embryonic lethality, while conditional knock-out in embryonic germ cells results in failure to establish a robust stem cell population. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Sall4
M08979_2.00
Mus musculus
CMCWCCCHNN

NNDGGGWGKG
Misc
Kulakovskiy et al.(2013)
SALL4_MOUSE.H11MO.0.A
(Direct) (Direct)
Sall4
M10341_2.00
Mus musculus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$DRRS_05
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
SALL4
M08866_2.00
Homo sapiens
CMCWCCCHNN

NNDGGGWGKG
Misc
Kulakovskiy et al.(2013)
SALL4_HUMAN.H11MO.0.B
0.810 0.935
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000029061 C2H2 ZF 387 409
ENSMUSP00000029061 C2H2 ZF 415 437
ENSMUSP00000029061 C2H2 ZF 601 623
ENSMUSP00000029061 C2H2 ZF 633 655
ENSMUSP00000029061 C2H2 ZF 880 902
ENSMUSP00000029061 C2H2 ZF 908 930
ENSMUSP00000074556 C2H2 ZF 91 113
ENSMUSP00000074556 C2H2 ZF 119 141
ENSMUSP00000099363 C2H2 ZF 436 458
ENSMUSP00000099363 C2H2 ZF 464 486
ENSMUSP00000119628 C2H2 ZF 64 86
ENSMUSP00000119628 C2H2 ZF 96 118

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

36 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
SALL4 Echinops telfairi ENSETEG00000012475 N 0.821
Sall4 Rattus norvegicus ENSRNOG00000050035 I 0.814
SALL4 Microcebus murinus ENSMICG00000000027 I 0.810
SALL4 Gorilla gorilla ENSGGOG00000001832 I 0.810
ENSPANG00000021792 Papio anubis ENSPANG00000021792 I 0.810
SALL4 Tursiops truncatus ENSTTRG00000007753 I 0.810
SALL4 Pan troglodytes ENSPTRG00000013631 I 0.810
SALL4 Homo sapiens ENSG00000101115 D 0.810
ENSNLEG00000007013 Nomascus leucogenys ENSNLEG00000007013 I 0.810
SALL4 Macaca mulatta ENSMMUG00000003870 I 0.810
SALL4 Dasypus novemcinctus ENSDNOG00000040633 I 0.810
ENSCJAG00000000591 Callithrix jacchus ENSCJAG00000000591 I 0.810
SALL4 Erinaceus europaeus ENSEEUG00000003649 I 0.810
ENSCSAG00000015269 Chlorocebus sabaeus ENSCSAG00000015269 I 0.810
ENSSTOG00000025002 Ictidomys tridecemlineatus ENSSTOG00000025002 I 0.808
SALL4 Equus caballus ENSECAG00000018533 N 0.803
ENSCJAG00000021107 Callithrix jacchus ENSCJAG00000021107 N 0.803
SALL4 Pteropus vampyrus ENSPVAG00000002075 I 0.802
ENSP00000217086 Macaca fascicularis ENSP00000217086 I 0.800
SALL4 Loxodonta africana ENSLAFG00000004309 I 0.800
SALL4 Sus scrofa ENSSSCG00000007479 I 0.797
ENSMLUG00000007060 Myotis lucifugus ENSMLUG00000007060 I 0.797
ENSTSYG00000007359 Tarsius syrichta ENSTSYG00000007359 I 0.779
ENSCAFG00000011738 Canis familiaris ENSCAFG00000011738 I 0.774
SALL4 Ochotona princeps ENSOPRG00000011640 I 0.774
ENSAMEG00000013250 Ailuropoda melanoleuca ENSAMEG00000013250 I 0.774
ENSPPYG00000011138 Pongo abelii ENSPPYG00000011138 I 0.774
ENSMPUG00000017543 Mustela putorius furo ENSMPUG00000017543 I 0.774
SALL4 Otolemur garnettii ENSOGAG00000013799 I 0.774
ENSMLUG00000008405 Myotis lucifugus ENSMLUG00000008405 I 0.772
SALL4 Felis catus ENSFCAG00000002822 I 0.772
SALL4 Bos taurus ENSBTAG00000003101 I 0.764
SALL4 Oryctolagus cuniculus ENSOCUG00000011797 I 0.761
Ogr03507 Ophisaurus gracilis Ogr03507 N 0.758
ENSTGUG00000018244 Taeniopygia guttata ENSTGUG00000018244 N 0.758