Zbtb7b (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000028042 T101071_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of alpha-beta T cell activation. Acts upstream of or within regulation of alpha-beta T cell differentiation and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; sensory organ; and skin. Orthologous to human ZBTB7B (zinc finger and BTB domain containing 7B). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Zbtb7b
M00135_2.00		 Mus musculus
NKMCCCCNNN
NNNGGGGKMN		 PBM
Badis et al.(2009)
Zbtb7b_1054		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZBTB7B
M02895_2.00 		Homo sapiens
DCGACCMCCVAN
NTBGGKGGTCGH		 SELEX
Jolma et al.(2013)
ZBTB7B_1 		0.827 1.000
ZBTB7B
M04497_2.00 		Homo sapiens
DCGACCACCN
NGGTGGTCGH		 SELEX
Yin et al.(2017)
ZBTB7B_eDBD_HT-SELEX 		0.827 1.000
ZBTB7B
M10233_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CKROX_Q2 		0.827 1.000
ZBTB7B
M04498_2.00 		Homo sapiens
DCGMCCACCN
NGGTGGKCGH		 SELEX
Yin et al.(2017)
ZBTB7B_eDBD_Methyl-HT-SELEX 		0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00135_2.00 C2H2 ZF 16 38
M00135_2.00 C2H2 ZF 44 66
M00135_2.00 C2H2 ZF 72 94
M00135_2.00 C2H2 ZF 100 121

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000029677 C2H2 ZF 350 372
ENSMUSP00000029677 C2H2 ZF 378 400
ENSMUSP00000029677 C2H2 ZF 406 428
ENSMUSP00000029677 C2H2 ZF 434 455
ENSMUSP00000103055 C2H2 ZF 350 372
ENSMUSP00000103055 C2H2 ZF 378 400
ENSMUSP00000103055 C2H2 ZF 406 428
ENSMUSP00000103055 C2H2 ZF 434 455
ENSMUSP00000103056 C2H2 ZF 350 372
ENSMUSP00000103056 C2H2 ZF 378 400
ENSMUSP00000103056 C2H2 ZF 406 428
ENSMUSP00000103056 C2H2 ZF 434 455
ENSMUSP00000103058 C2H2 ZF 350 372
ENSMUSP00000103058 C2H2 ZF 378 400
ENSMUSP00000103058 C2H2 ZF 406 428
ENSMUSP00000103058 C2H2 ZF 434 455

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

Invalid Input OrderBy

42 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action