Klf16 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000035397 T101126_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within dopamine receptor signaling pathway and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and retina. Orthologous to human KLF16 (Kruppel like factor 16). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Klf16
M10346_2.00		 Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$BTEB4_02		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
KLF16
M02888_2.00 		Homo sapiens
VMCMCDCCCMC
GKGGGHGKGKB		 SELEX
Jolma et al.(2013)
KLF16_1 		0.794 0.942
KLF16
M04457_2.00 		Homo sapiens
VMCMCRCCCH
DGGGYGKGKB		 SELEX
Yin et al.(2017)
KLF16_eDBD_HT-SELEX 		0.794 0.942
KLF16
M04458_2.00 		Homo sapiens
RMCACGCCCH
DGGGCGTGKY		 SELEX
Yin et al.(2017)
KLF16_eDBD_Methyl-HT-SELEX 		0.794 0.942
KLF14
M02930_2.00 		Homo sapiens
DRHCACGCCCMYYH
DRRKGGGCGTGDYH		 SELEX
Jolma et al.(2013)
KLF14_1 		0.775 0.841
KLF14
M04657_2.00 		Homo sapiens
NRMCMCGCCCMYN
NRKGGGCGKGKYN		 SELEX
Yin et al.(2017)
KLF14_eDBD_HT-SELEX 		0.775 0.841
KLF14
M08398_2.00 		Homo sapiens
RGYCMCGCCCMCYN
NRGKGGGCGKGRCY		 ChIP-seq
Schmitges et al.(2016)
Q8TD94.MEME 		0.775 0.841
KLF14
M04658_2.00 		Homo sapiens
NRMCVCRCCCMYN
NRKGGGYGBGKYN		 SELEX
Yin et al.(2017)
KLF14_eDBD_Methyl-HT-SELEX 		0.775 0.841
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000048825 C2H2 ZF 126 150
ENSMUSP00000048825 C2H2 ZF 156 180
ENSMUSP00000048825 C2H2 ZF 186 208

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

33 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Klf16 Rattus norvegicus ENSRNOG00000033694 I 0.827
ENSOGAG00000034621 Otolemur garnettii ENSOGAG00000034621 I 0.827
ENSCPOG00000008649 Cavia porcellus ENSCPOG00000008649 I 0.827
KLF16 Bos taurus ENSBTAG00000038055 I 0.827
KLF16 Sus scrofa ENSSSCG00000024672 I 0.800
ENSPANG00000004273 Papio anubis ENSPANG00000004273 I 0.794
KLF16 Homo sapiens ENSG00000129911 D 0.794
ENSCSAG00000011915 Chlorocebus sabaeus ENSCSAG00000011915 I 0.794
ENSLAFG00000030262 Loxodonta africana ENSLAFG00000030262 I 0.791
ENSMPUG00000005061 Mustela putorius furo ENSMPUG00000005061 I 0.791
ENSAMEG00000005763 Ailuropoda melanoleuca ENSAMEG00000005763 I 0.791
KLF14 Dasypus novemcinctus ENSDNOG00000001139 I 0.791
ENSFCAG00000031475 Felis catus ENSFCAG00000031475 I 0.791
ENSBTAP00000042214-D1 Bos grunniens ENSBTAP00000042214-D1 I 0.791
KLF14 Choloepus hoffmanni ENSCHOG00000011864 I 0.791
KLF14 Canis familiaris ENSCAFG00000024771 I 0.790
KLF14 Oryctolagus cuniculus ENSOCUG00000022893 I 0.775
ENSPANG00000015615 Papio anubis ENSPANG00000015615 I 0.775
KLF14 Pan troglodytes ENSPTRG00000019701 I 0.775
KLF14 Macaca mulatta ENSMMUG00000012491 I 0.775
KLF14 Gorilla gorilla ENSGGOG00000006845 I 0.775
ENSNLEG00000018607 Nomascus leucogenys ENSNLEG00000018607 I 0.775
KLF14 Homo sapiens ENSG00000266265 D 0.775
ENSMICG00000004383 Microcebus murinus ENSMICG00000004383 I 0.775
ENSCSAG00000019140 Chlorocebus sabaeus ENSCSAG00000019140 I 0.775
ENSCJAG00000016430 Callithrix jacchus ENSCJAG00000016430 I 0.775
ENSSTOG00000025048 Ictidomys tridecemlineatus ENSSTOG00000025048 I 0.772
Klf14 Rattus norvegicus ENSRNOG00000027557 I 0.772
ENSPPYG00000018009 Pongo abelii ENSPPYG00000018009 I 0.772
Klf14 Mus musculus ENSMUSG00000073209 I 0.772
KLF14 Ochotona princeps ENSOPRG00000002603 I 0.772
KLF14 Otolemur garnettii ENSOGAG00000030933 I 0.772
ENSCPOG00000027023 Cavia porcellus ENSCPOG00000027023 I 0.765