Zfp281 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000041483 T101166_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis and stem cell differentiation. Predicted to be located in nucleoplasm. Is expressed in several structures, including branchial arch; extraembryonic component; forelimb bud; genitourinary system; and limb. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Zfp281
M00139_2.00		 Mus musculus
NHDCCCCCHH
DDGGGGGHDN		 PBM
Badis et al.(2009)
Zfp281_0973		 (Direct) (Direct)
Zfp281
M08025_2.00		 Mus musculus
CCCCWCCCCCMVCHB
VDGBKGGGGGWGGGG		 ChIP-seq
Chen et al.(2011)
GSE11329_zfp281		 (Direct) (Direct)
Zfp281
M08999_2.00		 Mus musculus
CCCCTCCCCCMMCBB
VVGKKGGGGGAGGGG		 Misc
Kulakovskiy et al.(2013)
ZN281_MOUSE.H11MO.0.A		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZNF281
M04509_2.00 		Homo sapiens
SCCCCTCCCCCM
KGGGGGAGGGGS		 SELEX
Yin et al.(2017)
ZNF281_eDBD_HT-SELEX 		0.827 1.000
ZNF281
M08321_2.00 		Homo sapiens
BNCCCCTCCCCC
GGGGGAGGGGNV		 ChIP-seq
Schmitges et al.(2016)
Q9Y2X9_1-4.RCADE 		0.827 1.000
ZNF281
M08906_2.00 		Homo sapiens
BCCCCTCCCCCHNYN
NRNDGGGGGAGGGGV		 Misc
Kulakovskiy et al.(2013)
ZN281_HUMAN.H11MO.0.A 		0.827 1.000
ZNF281
M10237_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZFP281_01 		0.827 1.000
ZNF281
M04510_2.00 		Homo sapiens
RCCCMTCCCCCR
YGGGGGAKGGGY		 SELEX
Yin et al.(2017)
ZNF281_eDBD_Methyl-HT-SELEX 		0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00139_2.00 C2H2 ZF 16 38
M00139_2.00 C2H2 ZF 44 66
M00139_2.00 C2H2 ZF 72 94
M00139_2.00 C2H2 ZF 100 121

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000039003 C2H2 ZF 258 280
ENSMUSP00000039003 C2H2 ZF 286 308
ENSMUSP00000039003 C2H2 ZF 314 336
ENSMUSP00000039003 C2H2 ZF 342 363
ENSMUSP00000107677 C2H2 ZF 258 280
ENSMUSP00000107677 C2H2 ZF 286 308
ENSMUSP00000107677 C2H2 ZF 314 336
ENSMUSP00000107677 C2H2 ZF 342 363

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

Invalid Input OrderBy

67 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action