NCBI Gene Info:Enables sequence-specific DNA binding activity. Involved in several processes, including Notch signaling pathway; negative regulation of cold-induced thermogenesis; and positive regulation of BMP signaling pathway. Acts upstream of or within several processes, including cerebellar granule cell precursor proliferation; protein localization to cilium; and smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Used to study Dandy-Walker syndrome and cerebellar disease. Human ortholog(s) of this gene implicated in nephronophthisis 14. Orthologous to human ZNF423 (zinc finger protein 423). [provided by Alliance of Genome Resources, Apr 2022] |