Osr1 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000048387 T101234_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development; cellular response to retinoic acid; and intermediate mesoderm development. Predicted to be located in cytosol. Predicted to be extrinsic component of membrane. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human OSR1 (odd-skipped related transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Osr1
M00144_2.00		 Mus musculus
NVCTHCYNN
NNRGDAGBN		 PBM
Badis et al.(2009)
Osr1_3033		 (Direct) (Direct)
Osr1
M01174_2.00		 Mus musculus
GCTACYGT
ACRGTAGC		 PBM
Lambert et al.(2019)
pTH5339		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
OSR1
M04477_2.00 		Homo sapiens
NGCTACYGTD
HACRGTAGCN		 SELEX
Yin et al.(2017)
OSR1_eDBD_HT-SELEX 		0.827 1.000
OSR1
M04478_2.00 		Homo sapiens
NGCTACYGTD
HACRGTAGCN		 SELEX
Yin et al.(2017)
OSR1_eDBD_Methyl-HT-SELEX 		0.827 1.000
Osr2
M00132_2.00 		Mus musculus
NGCTWCYGNN
NNCRGWAGCN		 PBM
Badis et al.(2009)
Osr2_1727 		0.811 0.986
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00144_2.00 C2H2 ZF 16 38
M00144_2.00 C2H2 ZF 44 66
M00144_2.00 C2H2 ZF 72 94
M01174_2.00 C2H2 ZF 1 23
M01174_2.00 C2H2 ZF 29 51
M01174_2.00 C2H2 ZF 57 79

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000055486 C2H2 ZF 175 197
ENSMUSP00000055486 C2H2 ZF 203 225
ENSMUSP00000055486 C2H2 ZF 231 253

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

Invalid Input OrderBy

104 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action