IRF5 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000128604 T107583_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
IRF5
M3479_1.02
Homo sapiens Transfac
license
required
Transfac
license
required
Transfac
Matys et al.(2006)
V$IRF5_Q3
(Direct)
IRF5
M5574_1.02
Homo sapiens
YCGAAACCGAAMCY

RGKTTCGGTTTCGR
SELEX
Jolma et al.(2013)
IRF5_1
(Direct)
IRF5
M5575_1.02
Homo sapiens
HACCGAAACYV

BRGTTTCGGTD
SELEX
Jolma et al.(2013)
IRF5_2
(Direct)
IRF5
M6311_1.02
Homo sapiens
DAAAGGRAARCNAAAWSWGM

KCWSWTTTNGYTTYCCTTTH
HocoMoco
Kulakovskiy et al.(2013)
IRF5_f1
(Direct)

Motifs inferred from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
For this family, TFs with DBD identity >= 1 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000249375 IRF 14 123
ENSP00000340338 IRF 14 123
ENSP00000349770 IRF 14 123
ENSP00000385352 IRF 14 123
ENSP00000391780 IRF 14 123
ENSP00000407935 IRF 14 123
ENSP00000409106 IRF 14 123
ENSP00000414903 IRF 14 123
ENSP00000417454 IRF 14 59
ENSP00000417770 IRF 14 123
ENSP00000418037 IRF 14 123
ENSP00000418534 IRF 14 123
ENSP00000419056 IRF 14 106
ENSP00000419149 IRF 14 123
ENSP00000419950 IRF 14 123
ENSP00000420274 IRF 14 72

Links

Other IRF family TFs
Other Homo sapiens TFs

4 Related TFs

Name Species Gene ID Motif Evidence DBD
Identity
Action
IRF5 Pan troglodytes ENSPTRG00000019675 I 1.000
ENSPPYG00000017989 Pongo pygmaeus ENSPPYG00000017989 I 1.000
IRF5 Gorilla gorilla ENSGGOG00000012013 I 1.000