Bcl6 (Rattus norvegicus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSRNOG00000001843 T108870_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of regulatory T cell differentiation; regulation of gene expression; and type 2 immune response. Predicted to act upstream of or within several processes, including hemopoiesis; negative regulation of signal transduction; and regulation of lymphocyte activation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in nucleoplasm. Predicted to colocalize with replication fork. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
BCL6
M00228_2.00 		Homo sapiens
NNVNDVRANN
NNTYBHNBNN		 PBM
Barrera et al.(2016)
BCL6_REF 		0.827 1.000
BCL6
M04424_2.00 		Homo sapiens
NYGCTTTCKAGGAAHN
NDTTCCTMGAAAGCRN		 SELEX
Yin et al.(2017)
BCL6_eDBD_HT-SELEX_1 		0.827 1.000
BCL6
M04425_2.00 		Homo sapiens
NDTTCCTMGAWWRCVN
NBGYWWTCKAGGAAHN		 SELEX
Yin et al.(2017)
BCL6_eDBD_HT-SELEX_2 		0.827 1.000
Bcl6
M08097_2.00 		Mus musculus
NDCYYTCYAGGAAN
NTTCCTRGARRGHN		 ChIP-seq
Mathelier et al.(2014)
MA0463.1 		0.827 1.000
Bcl6
M08024_2.00 		Mus musculus
HYNBHHWBWSHTCHYNYYYYYYNBYYHYYH
DRRDRRVNRRRRRRNRDGADSWVWDDVNRD		 ChIP-seq
Chen et al.(2011)
SRP001843_Bcl6_IgG_LPSstim 		0.827 1.000
BCL6
M08877_2.00 		Homo sapiens
NNMYYTCYAGGAA
TTCCTRGARRKNN		 Misc
Kulakovskiy et al.(2013)
BCL6_HUMAN.H11MO.0.A 		0.827 1.000
Bcl6
M08972_2.00 		Mus musculus
NNMTYTCYAGGAA
TTCCTRGARAKNN		 Misc
Kulakovskiy et al.(2013)
BCL6_MOUSE.H11MO.0.A 		0.827 1.000
Bcl6
M09513_2.00 		Mus musculus
NNNNYTTCYWGGAAN
NTTCCWRGAARNNNN		 Misc
Heinz et al.(2010)
Liver-Bcl6_GSE31578 		0.827 1.000
BCL6
M10180_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$BCL6_01 		0.827 1.000
BCL6
M10181_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$BCL6_02 		0.827 1.000
BCL6
M10182_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$BCL6_Q3_01 		0.827 1.000
BCL6
M10183_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$BCL6_Q3 		0.827 1.000
BCL6
M10184_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$BCL6_Q6 		0.827 1.000
BCL6
M04426_2.00 		Homo sapiens
NTGCTTTCTAGGAAHN
NDTTCCTAGAAAGCAN		 SELEX
Yin et al.(2017)
BCL6_eDBD_Methyl-HT-SELEX_1 		0.827 1.000
BCL6
M04427_2.00 		Homo sapiens
NDTTCCTMGAWWRCVN
NBGYWWTCKAGGAAHN		 SELEX
Yin et al.(2017)
BCL6_eDBD_Methyl-HT-SELEX_2 		0.827 1.000
BCL6
M00227_2.00 		Homo sapiens
NTAATTRWNN
NNWYAATTAN		 PBM
Barrera et al.(2016)
BCL6_H676Y 		0.821 0.964
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000002522 C2H2 ZF 519 542
ENSRNOP00000002522 C2H2 ZF 547 569
ENSRNOP00000002522 C2H2 ZF 575 597
ENSRNOP00000002522 C2H2 ZF 603 625
ENSRNOP00000002522 C2H2 ZF 631 653
ENSRNOP00000002522 C2H2 ZF 659 682

Links

Other C2H2 ZF family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

53 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action