CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Glis2
(
Rattus norvegicus
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSRNOG00000004766
T108895_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development; negative regulation of smoothened signaling pathway; and regulation of transcription, DNA-templated. Predicted to act upstream of or within hematopoietic stem cell homeostasis; kidney development; and positive regulation of protein localization to nucleus. Predicted to be located in cytoplasm; non-motile cilium; and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Glis2
M00129_2.00
Mus musculus
NKACCCCYYNN
NNRRGGGGTMN
PBM
Badis et al.(2009)
Glis2_1757
0.827
1.000
GLIS2
M02887_2.00
Homo sapiens
KACCCCCCRCRDHG
CDHYGYGGGGGGTM
SELEX
Jolma et al.(2013)
GLIS2_1
0.827
0.986
GLIS2
M04449_2.00
Homo sapiens
RCCCCCCRCRWHGH
DCDWYGYGGGGGGY
SELEX
Yin et al.(2017)
GLIS2_eDBD_HT-SELEX
0.827
0.986
GLIS2
M04450_2.00
Homo sapiens
DCWHYGYDGGGGGT
ACCCCCHRCRDWGH
SELEX
Yin et al.(2017)
GLIS2_eDBD_Methyl-HT-SELEX
0.827
0.986
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000006680
C2H2 ZF
235
257
HRCPTCNKSFSRLENLKIHNRSH
ENSRNOP00000006680
C2H2 ZF
263
287
YVCPYEGCNKRYSNSSDRFKHTRTH
ENSRNOP00000006680
C2H2 ZF
293
317
YYCKMPGCHKRYTDPSSLRKHIKAH
Links
Other
C2H2 ZF
family TFs
Other
Rattus norvegicus
TFs
59 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy