Bcl11b (Rattus norvegicus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSRNOG00000005776 T108906_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in hematopoietic stem cell migration; lymphoid lineage cell migration into thymus; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; cell morphogenesis involved in differentiation; and regulation of keratinocyte proliferation. Predicted to be located in neuron projection. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 49. Orthologous to human BCL11B (BAF chromatin remodeling complex subunit BCL11B). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
BCL11B
M04453_2.00 		Homo sapiens
GTGAACGBNDNNVCTACAC
GTGTAGBNNHNVCGTTCAC		 SELEX
Yin et al.(2017)
BCL11B_eDBD_HT-SELEX 		0.827 1.000
BCL11B
M04454_2.00 		Homo sapiens
GTGAACGBNDNHVCTACAC
GTGTAGBDNHNVCGTTCAC		 SELEX
Yin et al.(2017)
BCL11B_eDBD_Methyl-HT-SELEX 		0.827 1.000
BCL11A
M07926_2.00 		Homo sapiens
BTYTCASTTCCYYHH
DDRRGGAASTGARAV		 ChIP-seq
Gerstein et al.(2012)
GM12878_BCL11A_HudsonAlpha 		0.806 0.947
BCL11A
M08881_2.00 		Homo sapiens
BHBYCABTTCCYBHNYN
NRNDVRGGAAVTGRVDV		 Misc
Kulakovskiy et al.(2013)
BC11A_HUMAN.H11MO.0.A 		0.806 0.947
BCL11A
M10187_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$BCL11A_02 		0.806 0.947
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000007602 C2H2 ZF 464 485
ENSRNOP00000007602 C2H2 ZF 491 513
ENSRNOP00000007602 C2H2 ZF 823 845
ENSRNOP00000007602 C2H2 ZF 851 873
ENSRNOP00000007602 C2H2 ZF 881 904
ENSRNOP00000068641 C2H2 ZF 423 444
ENSRNOP00000068641 C2H2 ZF 450 472
ENSRNOP00000068641 C2H2 ZF 782 804
ENSRNOP00000068641 C2H2 ZF 810 832
ENSRNOP00000068641 C2H2 ZF 840 863
ENSRNOP00000069404 C2H2 ZF 355 376
ENSRNOP00000069404 C2H2 ZF 382 404
ENSRNOP00000069404 C2H2 ZF 714 736
ENSRNOP00000069404 C2H2 ZF 742 764
ENSRNOP00000069404 C2H2 ZF 772 795

Links

Other C2H2 ZF family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

128 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action