CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Sp7
(
Rattus norvegicus
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSRNOG00000014082
T108987_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DEAD/H-box RNA helicase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in hematopoietic stem cell differentiation; positive regulation of stem cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within osteoblast differentiation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Sp7
M09009_2.00
Mus musculus
VHAVCCTRTAATTW
WAATTAYAGGBTDB
Misc
Kulakovskiy et al.(2013)
SP7_MOUSE.H11MO.0.A
0.827
1.000
SP7
M10258_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$OSX_Q3
0.827
1.000
SP8
M02898_2.00
Homo sapiens
VMCACBCCCMCH
DGKGGGVGTGKB
SELEX
Jolma et al.(2013)
SP8_1
0.764
0.855
SP8
M04517_2.00
Homo sapiens
NMCMCGCCCMYH
DRKGGGCGKGKN
SELEX
Yin et al.(2017)
SP8_eDBD_HT-SELEX
0.764
0.855
SP9
M04645_2.00
Homo sapiens
VMCMCGCCCMYH
DRKGGGCGKGKB
SELEX
Yin et al.(2017)
SP9_eDBD_HT-SELEX
0.764
0.855
SP8
M04518_2.00
Homo sapiens
RHCACGCCCMYH
DRKGGGCGTGDY
SELEX
Yin et al.(2017)
SP8_eDBD_Methyl-HT-SELEX
0.764
0.855
SP9
M04646_2.00
Homo sapiens
RYCACGCCCMYH
DRKGGGCGTGRY
SELEX
Yin et al.(2017)
SP9_eDBD_Methyl-HT-SELEX
0.764
0.855
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000018828
C2H2 ZF
291
315
HSCHIPGCGKVYGKASHLKAHLRWH
ENSRNOP00000018828
C2H2 ZF
321
345
FVCNWLFCGKRFTRSDELERHVRTH
ENSRNOP00000018828
C2H2 ZF
351
373
FTCLLCSKRFTRSDHLSKHQRTH
ENSRNOP00000074457
C2H2 ZF
273
297
HSCHIPGCGKVYGKASHLKAHLRWH
ENSRNOP00000074457
C2H2 ZF
303
327
FVCNWLFCGKRFTRSDELERHVRTH
ENSRNOP00000074457
C2H2 ZF
333
355
FTCLLCSKRFTRSDHLSKHQRTH
Links
Other
C2H2 ZF
family TFs
Other
Rattus norvegicus
TFs
139 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy