CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Hic2
(
Rattus norvegicus
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSRNOG00000051458
T109308_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human HIC2 (HIC ZBTB transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HIC2
M02902_2.00
Homo sapiens
RTGCCMVNN
NNBKGGCAY
SELEX
Jolma et al.(2013)
HIC2_1
0.827
1.000
Hic1
M00141_2.00
Mus musculus
RTGCCMNBN
NVNKGGCAY
PBM
Badis et al.(2009)
Hic1_2816
0.795
0.852
Hic1
M02933_2.00
Mus musculus
RTGCCAVCYBRTGCCAVC
GBTGGCAYVRGBTGGCAY
SELEX
Jolma et al.(2013)
Hic1_1
0.795
0.852
Hic1
M02934_2.00
Mus musculus
RTGCCAVCN
NGBTGGCAY
SELEX
Jolma et al.(2013)
Hic1_2
0.795
0.852
Hic1
M09003_2.00
Mus musculus
KGGCAMCCH
DGGKTGCCM
Misc
Kulakovskiy et al.(2013)
HIC1_MOUSE.H11MO.0.C
0.795
0.852
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000072722
C2H2 ZF
448
470
YVCIPCAKGFPSSEQLNAHVETH
ENSRNOP00000072722
C2H2 ZF
512
534
FKCSVCEKTYKDPATLRQHEKTH
ENSRNOP00000072722
C2H2 ZF
540
562
FPCNICGKMFTQRGTMTRHMRSH
ENSRNOP00000072722
C2H2 ZF
568
590
FACDECGMRFTRQYRLTEHMRVH
ENSRNOP00000072722
C2H2 ZF
596
618
YECQLCGGKFTQQRNLISHLRMH
Links
Other
C2H2 ZF
family TFs
Other
Rattus norvegicus
TFs
64 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy