ovo (Drosophila melanogaster)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 FBgn0003028 T114405_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables sequence-specific DNA binding activity and transcription coactivator binding activity. Involved in several processes, including adult feeding behavior; regionalization; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including cephalic furrow; extended germ band embryo; gonad; head segment; and integumentary system. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to several human genes including OVOL1 (ovo like transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ovo
M02671_2.00		 Drosophila melanogaster
DCNGTTWSD
HSWAACNGH		 SELEX
Mathelier et al.(2014)
MA0126.1		 (Direct) (Direct)
ovo
M03669_2.00		 Drosophila melanogaster
DNMCCGTTA
TAACGGKNH		 SELEX
Nitta et al.(2015)
ovo_1		 (Direct) (Direct)
ovo
M06064_2.00		 Drosophila melanogaster
CHGTTAHW
WDTAACDG		 B1H
Zhu et al.(2011)
ovo_FlyReg_FBgn0003028		 (Direct) (Direct)
ovo
M06065_2.00		 Drosophila melanogaster
RGTHCCGTTAT
ATAACGGDACY		 B1H
Zhu et al.(2011)
ovo_SANGER_5_FBgn0003028		 (Direct) (Direct)
ovo
M06066_2.00		 Drosophila melanogaster
DDTMCCGTTABNYN
NRNVTAACGGKAHH		 B1H
Zhu et al.(2011)
ovo_SOLEXA_5_FBgn0003028		 (Direct) (Direct)
ovo
M09662_2.00		 Drosophila melanogaster
DCNGTTAMWNNDV
BHNNWKTAACNGH		 Misc
Kulakovskiy et al.(2009)
ovo		 (Direct) (Direct)
ovo
M10373_2.00		 Drosophila melanogaster
NNNDCNGTTWSDDNN
NNHHSWAACNGHNNN		 Transfac
Matys et al.(2006)
I$OVO_01		 (Direct) (Direct)
ovo
M10374_2.00		 Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$OVO_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
lin-48
M00614_2.00 		Caenorhabditis elegans
HCCGTTAB
VTAACGGD		 PBM
Narasimhan et al.(2015)
pTH9155 		0.790 0.826
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0070706 C2H2 ZF 1197 1219
FBpp0070706 C2H2 ZF 1225 1247
FBpp0070706 C2H2 ZF 1253 1276
FBpp0070707 C2H2 ZF 1068 1090
FBpp0070707 C2H2 ZF 1096 1118
FBpp0070707 C2H2 ZF 1124 1147
FBpp0070708 C2H2 ZF 821 843
FBpp0070708 C2H2 ZF 849 871
FBpp0070708 C2H2 ZF 877 900
FBpp0099822 C2H2 ZF 874 896
FBpp0099822 C2H2 ZF 902 924
FBpp0099822 C2H2 ZF 930 953
FBpp0291128 C2H2 ZF 1197 1219
FBpp0291128 C2H2 ZF 1225 1247
FBpp0291128 C2H2 ZF 1253 1276

Links

Other C2H2 ZF family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

70 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action