ush (Drosophila melanogaster)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 FBgn0003963 T114415_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including animal organ development; embryonic development via the syncytial blastoderm; and regulation of cellular biosynthetic process. Located in nucleus. Is expressed in several structures, including blastoderm embryo; ectoderm; embryonic/larval circulatory system; epithelium; and extended germ band embryo. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to several human genes including ZFPM2 (zinc finger protein, FOG family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0077723 C2H2 ZF 883 904
FBpp0077723 C2H2 ZF 910 932
FBpp0301730 C2H2 ZF 890 911
FBpp0301730 C2H2 ZF 917 939
FBpp0302929 C2H2 ZF 883 904
FBpp0302929 C2H2 ZF 910 932
FBpp0305227 C2H2 ZF 867 888
FBpp0305227 C2H2 ZF 894 916
FBpp0305228 C2H2 ZF 890 911
FBpp0305228 C2H2 ZF 917 939

Links

Other C2H2 ZF family TFs
Other Drosophila melanogaster TFs

7 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
GM16748 Drosophila sechellia FBgn0171661 N 0.827
GG24725 Drosophila erecta FBgn0116856 N 0.827
GE16880 Drosophila yakuba FBgn0234370 N 0.827
GD23030 Drosophila simulans FBgn0194421 N 0.827
GH11230 Drosophila grimshawi FBgn0118710 N 0.807
GA15455 Drosophila pseudoobscura FBgn0075472 N 0.807