cbt (Drosophila melanogaster)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 FBgn0043364 T114596_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables sequence-specific DNA binding activity. Involved in several processes, including dorsal closure; positive regulation of BMP signaling pathway; and wing disc development. Located in nucleus. Is expressed in several structures, including embryonic/larval garland cell; extended germ band embryo; germline cell; imaginal disc; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to several human genes including KLF11 (Kruppel like factor 11). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
cbt
M03705_2.00		 Drosophila melanogaster
DMCACRCCCMY
RKGGGYGTGKH		 SELEX
Nitta et al.(2015)
cbt_1		 (Direct) (Direct)
cbt
M03706_2.00		 Drosophila melanogaster
RMCRCGCCCMCHH
DDGKGGGCGYGKY		 SELEX
Nitta et al.(2015)
cbt_2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
KLF15
M04511_2.00 		Homo sapiens
VHCMCVCCCMYN
NRKGGGBGKGDB		 SELEX
Yin et al.(2017)
KLF15_eDBD_HT-SELEX 		0.757 0.681
KLF15
M04513_2.00 		Homo sapiens
VMCMCDCCCMCH
DGKGGGHGKGKB		 SELEX
Yin et al.(2017)
KLF15_FL_HT-SELEX 		0.757 0.681
KLF15
M08323_2.00 		Homo sapiens
SSCYNBCYCCDCCYC
GRGGHGGRGVNRGSS		 ChIP-seq
Schmitges et al.(2016)
Q9UIH9.MEME 		0.757 0.681
KLF15
M08907_2.00 		Homo sapiens
CCNYYCCYNBCYCCKCCYY
RRGGMGGRGVNRGGRRNGG		 Misc
Kulakovskiy et al.(2013)
KLF15_HUMAN.H11MO.0.A 		0.757 0.681
Klf15
M08987_2.00 		Mus musculus
CCNYYCCYNBCYCCKCCYY
RRGGMGGRGVNRGGRRNGG		 Misc
Kulakovskiy et al.(2013)
KLF15_MOUSE.H11MO.0.A 		0.757 0.681
KLF15
M10241_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$KLF15_Q2 		0.757 0.681
KLF15
M04512_2.00 		Homo sapiens
RCCMCGCCCMCH
DGKGGGCGKGGY		 SELEX
Yin et al.(2017)
KLF15_eDBD_Methyl-HT-SELEX 		0.757 0.681
KLF15
M04514_2.00 		Homo sapiens
GCCMCGCCCMCN
NGKGGGCGKGGC		 SELEX
Yin et al.(2017)
KLF15_FL_Methyl-HT-SELEX 		0.757 0.681
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0077743 C2H2 ZF 263 287
FBpp0077743 C2H2 ZF 293 317
FBpp0077743 C2H2 ZF 323 345
FBpp0077744 C2H2 ZF 182 206
FBpp0077744 C2H2 ZF 212 236
FBpp0077744 C2H2 ZF 242 264
FBpp0301733 C2H2 ZF 182 206
FBpp0301733 C2H2 ZF 212 236
FBpp0301733 C2H2 ZF 242 264

Links

Other C2H2 ZF family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

111 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action