egl-43 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00001207 T131552_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity. Involved in several processes, including regulation of cell fate specification; regulation of neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including MSaaaa; MSaaap; gonad; neurons; and somatic gonad precursor. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to several human genes including MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
egl-43
M00611_2.00		 Caenorhabditis elegans
NDNNCATCHN
NDGATGNNHN		 PBM
Narasimhan et al.(2015)
pTH10718		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00611_2.00 C2H2 ZF 51 73
M00611_2.00 C2H2 ZF 79 102

DNA Binding Domains

Protein ID Domain From To Sequence
R53.3a C2H2 ZF 159 181
R53.3a C2H2 ZF 187 209
R53.3a C2H2 ZF 444 466
R53.3a C2H2 ZF 472 495
R53.3b C2H2 ZF 223 245
R53.3b C2H2 ZF 251 274

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

5 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ANCCAN_14477 Ancylostoma caninum ANCCAN_14477 I 0.827
CJA10771 Caenorhabditis japonica CJA10771 I 0.827
SROB_0000239601 Schistosoma rodhaini SROB_0000239601 I 0.805
AMEC012935 Anopheles melas AMEC012935 I 0.798
ENSSTOG00000020440 Ictidomys tridecemlineatus ENSSTOG00000020440 I 0.787