lin-48 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00003033 T131560_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hindgut morphogenesis and nematode male tail tip morphogenesis. Located in nucleus. Is expressed in ciliated neurons; interfacial epithelial cell; intestine; labial sensillum; and tail. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to several human genes including OVOL1 (ovo like transcriptional repressor 1) and OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
lin-48
M00614_2.00		 Caenorhabditis elegans
HCCGTTAB
VTAACGGD		 PBM
Narasimhan et al.(2015)
pTH9155		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ovo
M03669_2.00 		Drosophila melanogaster
DNMCCGTTA
TAACGGKNH		 SELEX
Nitta et al.(2015)
ovo_1 		0.790 0.826
ovo
M06064_2.00 		Drosophila melanogaster
CHGTTAHW
WDTAACDG		 B1H
Zhu et al.(2011)
ovo_FlyReg_FBgn0003028 		0.790 0.826
ovo
M06065_2.00 		Drosophila melanogaster
RGTHCCGTTAT
ATAACGGDACY		 B1H
Zhu et al.(2011)
ovo_SANGER_5_FBgn0003028 		0.790 0.826
ovo
M06066_2.00 		Drosophila melanogaster
DDTMCCGTTABNYN
NRNVTAACGGKAHH		 B1H
Zhu et al.(2011)
ovo_SOLEXA_5_FBgn0003028 		0.790 0.826
ovo
M02671_2.00 		Drosophila melanogaster
DCNGTTWSD
HSWAACNGH		 SELEX
Mathelier et al.(2014)
MA0126.1 		0.790 0.826
ovo
M09662_2.00 		Drosophila melanogaster
DCNGTTAMWNNDV
BHNNWKTAACNGH		 Misc
Kulakovskiy et al.(2009)
ovo 		0.790 0.826
ovo
M10373_2.00 		Drosophila melanogaster
NNNDCNGTTWSDDNN
NNHHSWAACNGHNNN		 Transfac
Matys et al.(2006)
I$OVO_01 		0.790 0.826
ovo
M10374_2.00 		Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$OVO_Q6 		0.790 0.826
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00614_2.00 C2H2 ZF 51 73
M00614_2.00 C2H2 ZF 79 101
M00614_2.00 C2H2 ZF 107 130

DNA Binding Domains

Protein ID Domain From To Sequence
F34D10.5 C2H2 ZF 133 155
F34D10.5 C2H2 ZF 161 183
F34D10.5 C2H2 ZF 189 212

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

70 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action