pag-3 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00003909 T131567_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables transcription corepressor activity. Involved in several processes, including negative regulation of secretion by cell; neuroblast fate specification; and regulation of backward locomotion. Located in nucleus. Is expressed in several structures, including P1.aap; P11.aaap; P12.aaap; anal region; and neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gray platelet syndrome; platelet-type bleeding disorder 17; and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor) and GFI1B (growth factor independent 1B transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
pag-3
M00619_2.00		 Caenorhabditis elegans
NVAATCWSNN
NNSWGATTBN		 PBM
Narasimhan et al.(2015)
pTH9969		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00619_2.00 C2H2 ZF 51 73
M00619_2.00 C2H2 ZF 79 101
M00619_2.00 C2H2 ZF 107 129
M00619_2.00 C2H2 ZF 135 157
M00619_2.00 C2H2 ZF 163 186

DNA Binding Domains

Protein ID Domain From To Sequence
F45B8.4 C2H2 ZF 126 148
F45B8.4 C2H2 ZF 154 176
F45B8.4 C2H2 ZF 182 204
F45B8.4 C2H2 ZF 210 232
F45B8.4 C2H2 ZF 238 261

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

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6 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action