tra-1 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00006604 T131576_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity; and protein C-terminus binding activity. Involved in several processes, including female somatic sex determination; negative regulation of transcription by RNA polymerase II; and positive regulation of neuron apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including germ line; gonad; intestine; nervous system; and somatic gonad precursor. Human ortholog(s) of this gene implicated in several diseases, including Culler-Jones syndrome; Pallister-Hall syndrome; anodontia; holoprosencephaly 9; and synostosis (multiple). Orthologous to human GLI1 (GLI family zinc finger 1); GLI2 (GLI family zinc finger 2); and GLI3 (GLI family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
tra-1
M10386_2.00		 Caenorhabditis elegans Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
N$TRA1_01		 (Direct) (Direct)
tra-1
M10387_2.00		 Caenorhabditis elegans Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
N$TRA1_02		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
Y47D3A.6a C2H2 ZF 243 269
Y47D3A.6a C2H2 ZF 276 299
Y47D3A.6a C2H2 ZF 305 330
Y47D3A.6a C2H2 ZF 336 361
Y47D3A.6b C2H2 ZF 207 232
Y47D3A.6b C2H2 ZF 243 269

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

4 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CBG13188 Caenorhabditis briggsae CBG13188 I 0.824
CRE04883 Caenorhabditis remanei CRE04883 I 0.812
CBN25087 Caenorhabditis brenneri CBN25087 I 0.812
CJA00622 Caenorhabditis japonica CJA00622 I 0.809