| NCBI Gene Info:Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of MAP kinase activity; negative regulation of oocyte maturation; and negative regulation of ovulation. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including body wall musculature; hermaphrodite somatic gonadal cell; intestine; pharynx; and sperm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; asthma; and motor peripheral neuropathy. Orthologous to several human genes including EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022] |