sptf-3 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00012735 T131606_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including generation of neurons; nematode larval development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including MSpaa; g1AR; hypodermal cell; pharyngeal cell; and somatic nervous system. Orthologous to human SP6 (Sp6 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
sptf-3
M00632_2.00		 Caenorhabditis elegans
NNMCGCCCMY
RKGGGCGKNN		 PBM
Narasimhan et al.(2015)
pTH9394		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Sp1
M00765_2.00 		Mus musculus
NMCGCCCMY
RKGGGCGKN		 PBM
Weirauch et al.(2013)
pTH0978 		0.766 0.754
SP1
M02921_2.00 		Homo sapiens
RCCMCDCCCMH
DKGGGHGKGGY		 SELEX
Jolma et al.(2013)
SP1_1 		0.766 0.754
SP1
M04605_2.00 		Homo sapiens
NWRRCCACGCCCMCH
DGKGGGCGTGGYYWN		 SELEX
Yin et al.(2017)
SP1_eDBD_HT-SELEX 		0.766 0.754
SP1
M08096_2.00 		Homo sapiens
BYCCCKCCCCY
RGGGGMGGGRV		 ChIP-seq
Mathelier et al.(2014)
MA0079.3 		0.766 0.754
SP1
M08363_2.00 		Homo sapiens
CCCHNBCYCCDCCCY
RGGGHGGRGVNDGGG		 ChIP-seq
Schmitges et al.(2016)
P08047.MEME 		0.766 0.754
SP1
M08938_2.00 		Homo sapiens
BCSSSBCCHVGCCCCGCCCCYN
NRGGGGCGGGGCBDGGVSSSGV		 Misc
Kulakovskiy et al.(2013)
SP1_HUMAN.H11MO.0.A 		0.766 0.754
Sp1
M08963_2.00 		Mus musculus
CCCBKCYCCKCCCCCNBCYCSBSC
GSVSGRGVNGGGGGMGGRGMVGGG		 Misc
Kulakovskiy et al.(2013)
SP1_MOUSE.H11MO.0.A 		0.766 0.754
SP1
M10294_2.00 		Homo sapiens
DSCMHGCCYH
DRGGCDKGSH		 Transfac
Matys et al.(2006)
V$SP1_01 		0.766 0.754
SP1
M10295_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_02 		0.766 0.754
SP1
M10296_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_07 		0.766 0.754
SP1
M10297_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_08 		0.766 0.754
SP1
M10298_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_Q2_02 		0.766 0.754
SP1
M10299_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_Q3 		0.766 0.754
SP1
M10300_2.00 		Homo sapiens
VVCCCCGCCCMBN
NVKGGGCGGGGBB		 Transfac
Matys et al.(2006)
V$SP1_Q6 		0.766 0.754
SP1
M04606_2.00 		Homo sapiens
NWRGCCMCGCCCMYH
DRKGGGCGKGGCYWN		 SELEX
Yin et al.(2017)
SP1_eDBD_Methyl-HT-SELEX 		0.766 0.754
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00632_2.00 C2H2 ZF 51 73
M00632_2.00 C2H2 ZF 79 103
M00632_2.00 C2H2 ZF 109 131

DNA Binding Domains

Protein ID Domain From To Sequence
Y40B1A.4 C2H2 ZF 316 338
Y40B1A.4 C2H2 ZF 344 368
Y40B1A.4 C2H2 ZF 374 396

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

127 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action