CRZ1 (Saccharomyces cerevisiae)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 YNL027W T131853_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell wall chitin biosynthetic process; cellular response to blue light; and positive regulation of cellular response to drug. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to several human genes including KLF10 (Kruppel like factor 10); PATZ1 (POZ/BTB and AT hook containing zinc finger 1); and SP3 (Sp3 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CRZ1
M00038_2.00		 Saccharomyces cerevisiae
NNDCTRHGCCNN
NNGGCDYAGHNN		 PBM
Badis et al.(2008)
CRZ1_4531		 (Direct) (Direct)
CRZ1
M07468_2.00		 Saccharomyces cerevisiae
NNVMGCCHC
GDGGCKBNN		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0285.1		 (Direct) (Direct)
CRZ1
M08541_2.00		 Saccharomyces cerevisiae
NNVMGCCHC
GDGGCKBNN		 Misc
DeBoer et al.(2011)
YNL027W_516		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00038_2.00 C2H2 ZF 51 73
M00038_2.00 C2H2 ZF 79 101
M00038_2.00 C2H2 ZF 107 137

DNA Binding Domains

Protein ID Domain From To Sequence
YNL027W C2H2 ZF 569 591
YNL027W C2H2 ZF 597 619
YNL027W C2H2 ZF 625 655

Links

Other C2H2 ZF family TFs
Other Saccharomyces cerevisiae TFs

Invalid Input OrderBy

30 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action