PPARD (Homo sapiens)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 ENSG00000112033 T132748_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
PPARD
M6432_1.02
Homo sapiens
TGACCTBTNNCCTR

YAGGNNAVAGGTCA
HocoMoco
Kulakovskiy et al.(2013)
PPARD_f1
(Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
PPARA
M6431_1.02
Homo sapiens
TGACCTYTGNCCY

RGGNCARAGGTCA
HocoMoco
Kulakovskiy et al.(2013)
PPARA_f2
0.855
PPARA
M6430_1.02
Homo sapiens
TGACCTH

DAGGTCA
HocoMoco
Kulakovskiy et al.(2013)
PPARA_f1
0.855
PPARA
M3782_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PPARA_Q6
0.855
PPARA
M3781_1.02
Homo sapiens
TGAMCTWTGNCCTRGWTYWG

CWRAWCYAGGNCAWAGKTCA
Transfac
Matys et al.(2006)
V$PPARA_01
0.855
PPARG
M6434_1.02
Homo sapiens
TGACCTWYD

HRWAGGTCA
HocoMoco
Kulakovskiy et al.(2013)
PPARG_si
0.814
PPARG
M6433_1.02
Homo sapiens
NKKMMCYYTGMCCYMNWN

NWNKRGGKCARRGKKMMN
HocoMoco
Kulakovskiy et al.(2013)
PPARG_f1
0.814
PPARG
M3786_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PPARG_Q6
0.814
PPARG
M3784_1.02
Homo sapiens
AWBTRGGTCACNDTGACCTA

AASTAGGTCAHNGTGACCYA
Transfac
Matys et al.(2006)
V$PPARG_02
0.814
PPARG
M3785_1.02
Homo sapiens
TGAMCTTTRNCCYDVWW

WWBHRGGNYAAAGKTCA
Transfac
Matys et al.(2006)
V$PPARG_03
0.814
PPARG
M3783_1.02
Homo sapiens
HNBDTGACCTTTGACCYYHN

NNDRRGGTCAAAGGTCAHVN
Transfac
Matys et al.(2006)
V$PPARG_01
0.814
PPARG
M1894_1.02
Homo sapiens
WNTRGGTCAHNNTGACCYAS

STRGGTCANNDTGACCYANW
SELEX
Mathelier et al.(2014)
MA0066.1
0.814
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000310928 Nuclear receptor 72 140
ENSP00000337063 Nuclear receptor 72 140
ENSP00000353916 Nuclear receptor 72 140
ENSP00000410837 Nuclear receptor 72 140

Links

Other Nuclear receptor family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found