NR1I2 (Homo sapiens)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 ENSG00000144852 T132766_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
NR1I2
M6385_1.02
Homo sapiens
NTGAMCTYNNHKRAVYYHH

DDRRBTYMDNNRAGKTCAN
HocoMoco
Kulakovskiy et al.(2013)
NR1I2_f2
(Direct)
NR1I2
M6386_1.02
Homo sapiens
VTGAACTY

RAGTTCAB
HocoMoco
Kulakovskiy et al.(2013)
NR1I2_si
(Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000336528 Nuclear receptor 78 148
ENSP00000377319 Nuclear receptor 39 109
ENSP00000377321 Nuclear receptor 46 116
ENSP00000416285 Nuclear receptor 46 116
ENSP00000420297 Nuclear receptor 39 109
ENSP00000422637 Nuclear receptor 39 109

Links

Other Nuclear receptor family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found