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ENSBTAP00000024080-D1
(Bos grunniens)
C2H2 ZF
|
TF Information |
|---|
| Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
| PF00096 (zf-C2H2) |
IPR007087 |
ENSBTAP00000024080-D1 |
T134608_2.00 |
GigaDB (2015-Oct-22) |
| NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
| No direct experiments |
|
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|
|
Motifs from related TFs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
ZNF449
M04560_2.00 |
Homo sapiens |
NTGYTKGCWCGCGAB |
VTCGCGWGCMARCAN |
SELEX
Yin et al.(2017)
ZNF449_eDBD_HT-SELEX_1
|
0.824
|
0.988
|
ZNF449
M04561_2.00 |
Homo sapiens |
RCGCCCAACC |
GGTTGGGCGY |
SELEX
Yin et al.(2017)
ZNF449_eDBD_HT-SELEX_2
|
0.824
|
0.988
|
ZNF449
M08344_2.00 |
Homo sapiens |
NNVAGCCCARCCHNNNNNNNN |
NNNNNNNNDGGYTGGGCTBNN |
ChIP-seq
Schmitges et al.(2016)
Q6P9G9_1-7.RCADE
|
0.824
|
0.988
|
ZNF449
M08922_2.00 |
Homo sapiens |
VAGCCCARCCN |
NGGYTGGGCTB |
Misc
Kulakovskiy et al.(2013)
ZN449_HUMAN.H11MO.0.C
|
0.824
|
0.988
|
ZNF449
M04562_2.00 |
Homo sapiens |
MMGCCCMACC |
GGTKGGGCKK |
SELEX
Yin et al.(2017)
ZNF449_eDBD_Methyl-HT-SELEX_1
|
0.824
|
0.988
|
ZNF449
M04563_2.00 |
Homo sapiens |
NTGYTKGCDCGCGWB |
VWCGCGHGCMARCAN |
SELEX
Yin et al.(2017)
ZNF449_eDBD_Methyl-HT-SELEX_2
|
0.824
|
0.988
|
| For this family, TFs with SR scores > 0.755 will likely have a similar motif |