ENSP00000270722 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000270722 T134960_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
PRDM16
M10223_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PRDM16_03
0.827 1.000
PRDM16
M10224_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PRDM16_04
0.827 1.000
PRDM16
M10225_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PRDM16_05
0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000270722 C2H2 ZF 217 238
ENSP00000270722 C2H2 ZF 268 290
ENSP00000270722 C2H2 ZF 296 318
ENSP00000270722 C2H2 ZF 324 347
ENSP00000270722 C2H2 ZF 353 375
ENSP00000270722 C2H2 ZF 381 403
ENSP00000270722 C2H2 ZF 410 431
ENSP00000270722 C2H2 ZF 900 922
ENSP00000270722 C2H2 ZF 928 951
ENSP00000270722 C2H2 ZF 957 979

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

32 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
PRDM16 Gorilla gorilla ENSGGOG00000003763 I 0.827
ENSPPYG00000001968 Pongo abelii ENSPPYG00000001968 I 0.827
PRDM16 Homo sapiens ENSG00000142611 D 0.827
PRDM16 Macaca mulatta ENSMMUG00000009350 I 0.827
PRDM16 Loxodonta africana ENSLAFG00000001071 I 0.825
PRDM16 Meleagris gallopavo ENSMGAG00000001857 I 0.825
Brh_R007819 Buceros rhinoceros Brh_R007819 I 0.825
Alligator_sinensis_CCG011602.1 Alligator sinensis Alligator_sinensis_CCG011602.1 I 0.825
ENSAPLG00000005898 Anas platyrhynchos ENSAPLG00000005898 I 0.825
Gfo_R009744 Geospiza fortis Gfo_R009744 I 0.825
Afo_R003306 Aptenodytes forsteri Afo_R003306 I 0.825
ENSGALG00000001063 Gallus gallus ENSGALG00000001063 I 0.825
PRDM16 Bos taurus ENSBTAG00000018965 I 0.824
ENSP00000417899-D2 Bos grunniens ENSP00000417899-D2 I 0.824
XP_002938538 Xenopus tropicalis XP_002938538 I 0.824
PRDM16 Otolemur garnettii ENSOGAG00000005055 I 0.823
ENSPSIG00000004093 Pelodiscus sinensis ENSPSIG00000004093 I 0.823
PRDM16 Equus caballus ENSECAG00000017045 I 0.822
PRDM16 Canis familiaris ENSCAFG00000019473 I 0.819
PRDM16 Sus scrofa ENSSSCG00000021490 I 0.816
ENSLOCG00000005336 Lepisosteus oculatus ENSLOCG00000005336 I 0.809
Aan_R005955 Calypte anna Aan_R005955 I 0.803
ENSFALG00000009580 Ficedula albicollis ENSFALG00000009580 I 0.803
Ogr15306 Ophisaurus gracilis Ogr15306 I 0.800
PRDM16 Danio rerio ENSDARG00000078324 I 0.778
ENSGMOG00000015664 Gadus morhua ENSGMOG00000015664 I 0.777
ENSAMXG00000014024 Astyanax mexicanus ENSAMXG00000014024 I 0.775
si:ch211-263k4.2 Gasterosteus aculeatus ENSGACG00000006600 I 0.772
si:ch211-263k4.2 Oryzias latipes ENSORLG00000004492 I 0.772
ENSPFOG00000010341 Poecilia formosa ENSPFOG00000010341 I 0.772
ENSXMAG00000019072 Xiphophorus maculatus ENSXMAG00000019072 I 0.772
ENSONIG00000002121 Oreochromis niloticus ENSONIG00000002121 I 0.767