ENSP00000270722 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000270722 T134960_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
PRDM16
M10223_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PRDM16_03 		0.827 1.000
PRDM16
M10224_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PRDM16_04 		0.827 1.000
PRDM16
M10225_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PRDM16_05 		0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000270722 C2H2 ZF 217 238
ENSP00000270722 C2H2 ZF 268 290
ENSP00000270722 C2H2 ZF 296 318
ENSP00000270722 C2H2 ZF 324 347
ENSP00000270722 C2H2 ZF 353 375
ENSP00000270722 C2H2 ZF 381 403
ENSP00000270722 C2H2 ZF 410 431
ENSP00000270722 C2H2 ZF 900 922
ENSP00000270722 C2H2 ZF 928 951
ENSP00000270722 C2H2 ZF 957 979

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

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32 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action