ENSP00000278780 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000278780 T134970_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
OVOL2
M00235_2.00
Homo sapiens
NCCGYTANNN

NNNTARCGGN
PBM
Barrera et al.(2016)
OVOL2_REF
0.827 1.000
OVOL2
M04445_2.00
Homo sapiens
NNHCCGYTANNHN

NDNNTARCGGDNN
SELEX
Yin et al.(2017)
OVOL2_eDBD_HT-SELEX
0.827 1.000
OVOL2
M04447_2.00
Homo sapiens
DDWCCGTTABNHN

NDNVTAACGGWHH
SELEX
Yin et al.(2017)
OVOL2_FL_HT-SELEX
0.827 1.000
OVOL2
M10207_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MOVOB_01
0.827 1.000
OVOL2
M04446_2.00
Homo sapiens
NNWCCGTTANNHN

NDNNTAACGGWNN
SELEX
Yin et al.(2017)
OVOL2_eDBD_Methyl-HT-SELEX
0.827 1.000
OVOL2
M04448_2.00
Homo sapiens
DDWCCGTTABNHN

NDNVTAACGGWHH
SELEX
Yin et al.(2017)
OVOL2_FL_Methyl-HT-SELEX
0.827 1.000
Ovol2
M08993_2.00
Mus musculus
HCCGTTAN

NTAACGGD
Misc
Kulakovskiy et al.(2013)
OVOL2_MOUSE.H11MO.0.C
0.813 0.967
OVOL2
M00234_2.00
Homo sapiens
NCCGYTANNN

NNNTARCGGN
PBM
Barrera et al.(2016)
OVOL2_D228E
0.772 0.989
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000278780 C2H2 ZF 13 35
ENSP00000278780 C2H2 ZF 41 63
ENSP00000278780 C2H2 ZF 69 92
ENSP00000278780 C2H2 ZF 108 131

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

54 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSCSAG00000011547 Chlorocebus sabaeus ENSCSAG00000011547 I 0.827
OVOL2 Gorilla gorilla ENSGGOG00000024444 I 0.827
ENSNLEG00000009741 Nomascus leucogenys ENSNLEG00000009741 I 0.827
OVOL2 Homo sapiens ENSG00000125850 D 0.827
ENSPANG00000025538 Papio anubis ENSPANG00000025538 I 0.827
ENSPPYG00000010732 Pongo abelii ENSPPYG00000010732 I 0.827
ENSMMUG00000021621 Macaca mulatta ENSMMUG00000021621 I 0.827
OVOL2 Pan troglodytes ENSPTRG00000013280 I 0.827
ENSMICG00000017455 Microcebus murinus ENSMICG00000017455 I 0.825
OVOL2 Loxodonta africana ENSLAFG00000010597 I 0.825
Myotis_brandtii_Ovol2_10029083 Myotis brandtii Myotis_brandtii_Ovol2_10029083 I 0.825
OVOL2 Equus caballus ENSECAG00000007899 I 0.825
OVOL2 Oryctolagus cuniculus ENSOCUG00000012116 I 0.825
ENSMLUG00000026760 Myotis lucifugus ENSMLUG00000026760 I 0.825
OVOL2 Otolemur garnettii ENSOGAG00000030325 I 0.825
ENSSTOG00000024979 Ictidomys tridecemlineatus ENSSTOG00000024979 I 0.822
Ovol2 Dipodomys ordii ENSDORG00000016697 I 0.822
OVOL2 Pteropus vampyrus ENSPVAG00000001140 I 0.822
ENSSHAG00000018466 Sarcophilus harrisii ENSSHAG00000018466 I 0.819
ENSMPUG00000001295 Mustela putorius furo ENSMPUG00000001295 I 0.819
OVOL2 Monodelphis domestica ENSMODG00000005504 I 0.819
OVOL2 Felis catus ENSFCAG00000027530 I 0.819
ENSAMEG00000005266 Ailuropoda melanoleuca ENSAMEG00000005266 I 0.819
OVOL2 Gallus gallus ENSGALG00000008702 I 0.817
ENSOARG00000018244 Ovis aries ENSOARG00000018244 I 0.817
ENSMGAG00000006770 Meleagris gallopavo ENSMGAG00000006770 I 0.817
ENSSARG00000006563 Sorex araneus ENSSARG00000006563 I 0.816
OVOL2 Echinops telfairi ENSETEG00000006907 I 0.815
OVOL2 Ochotona princeps ENSOPRG00000015054 I 0.815
Ovol2 Rattus norvegicus ENSRNOG00000006850 I 0.813
Ovol2 Mus musculus ENSMUSG00000037279 D 0.813
OVOL2 Taeniopygia guttata ENSTGUG00000005909 I 0.812
Tal_R010801 Tyto alba Tal_R010801 I 0.812
Aan_R006310 Calypte anna Aan_R006310 I 0.812
ENSFALG00000007594 Ficedula albicollis ENSFALG00000007594 I 0.812
Afo_R007843 Aptenodytes forsteri Afo_R007843 I 0.812
Brh_R002739 Buceros rhinoceros Brh_R002739 I 0.812
ENSCPOG00000007912 Cavia porcellus ENSCPOG00000007912 I 0.811
OVOL2 Canis familiaris ENSCAFG00000005453 I 0.807
ENSAPLG00000016199 Anas platyrhynchos ENSAPLG00000016199 I 0.807
OVOL2 Tursiops truncatus ENSTTRG00000016430 I 0.805
ovol2 Xenopus tropicalis XB-GENE-854193 I 0.805
OVOL2 Bos taurus ENSBTAG00000008410 I 0.805
ENSBTAP00000011067-D1 Bos grunniens ENSBTAP00000011067-D1 I 0.805
ENSPSIG00000006768 Pelodiscus sinensis ENSPSIG00000006768 I 0.802
Cmyd_10010114 Chelonia mydas Cmyd_10010114 I 0.797
ENSOANG00000001250 Ornithorhynchus anatinus ENSOANG00000001250 I 0.797
Alligator_sinensis_CCG008208.1 Alligator sinensis Alligator_sinensis_CCG008208.1 I 0.797
ENSMEUG00000011922 Macropus eugenii ENSMEUG00000011922 I 0.780
Pvit_03654 Pogona vitticeps Pvit_03654 I 0.774
OVOL2 Callithrix jacchus ENSCJAG00000005049 I 0.767
OVOL2 Anolis carolinensis ENSACAG00000014216 I 0.766
Ogr08372 Ophisaurus gracilis Ogr08372 I 0.763
ENSTSYG00000012790 Tarsius syrichta ENSTSYG00000012790 I 0.762