ENSP00000304985 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000304985 T135041_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZFX
M08850_2.00
Homo sapiens
YBVGGCCTVS

SBAGGCCBVR
Misc
Kulakovskiy et al.(2013)
ZFX_HUMAN.H11MO.0.A
0.809 0.997
ZFX
M10098_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZFX_01
0.809 0.997
Zfx
M08100_2.00
Mus musculus
BBVRSCBVGGCCTV

BAGGCCBVGSYBVV
ChIP-seq
Mathelier et al.(2014)
MA0146.2
0.804 0.990
Zfx
M09017_2.00
Mus musculus
VVSVSBNBBAGGCCBVGSH

DSCBVGGCCTVVNVSBSBB
Misc
Kulakovskiy et al.(2013)
ZFX_MOUSE.H11MO.0.B
0.804 0.990
Zfx
M09517_2.00
Mus musculus
BNAGGCCT

AGGCCTNV
Misc
Heinz et al.(2010)
mES-Zfx_GSE11431
0.804 0.990
Zfx
M00788_2.00
Mus musculus
NRGGCCNNN

NNNGGCCYN
PBM
Weirauch et al.(2013)
pTH2933
0.803 0.987
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000304985 C2H2 ZF 442 464
ENSP00000304985 C2H2 ZF 473 495
ENSP00000304985 C2H2 ZF 505 527
ENSP00000304985 C2H2 ZF 536 559
ENSP00000304985 C2H2 ZF 565 587
ENSP00000304985 C2H2 ZF 593 616
ENSP00000304985 C2H2 ZF 622 644
ENSP00000304985 C2H2 ZF 650 673
ENSP00000304985 C2H2 ZF 679 701
ENSP00000304985 C2H2 ZF 707 730
ENSP00000304985 C2H2 ZF 736 758
ENSP00000304985 C2H2 ZF 764 787
ENSP00000304985 C2H2 ZF 793 816

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

40 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Myotis_brandtii_ZFX_10010226 Myotis brandtii Myotis_brandtii_ZFX_10010226 I 0.827
ENSNLEG00000010044 Nomascus leucogenys ENSNLEG00000010044 I 0.827
ENSMPUG00000000105 Mustela putorius furo ENSMPUG00000000105 I 0.827
ZFX Tursiops truncatus ENSTTRG00000012488 I 0.827
ZFY Myotis lucifugus ENSMLUG00000003962 I 0.827
ENSBTAP00000010165-D1 Bos grunniens ENSBTAP00000010165-D1 I 0.827
ENSOARG00000017137 Ovis aries ENSOARG00000017137 I 0.827
ENSSSCG00000021322 Sus scrofa ENSSSCG00000021322 I 0.827
ENSSTOG00000007158 Ictidomys tridecemlineatus ENSSTOG00000007158 I 0.827
ZFX Pteropus vampyrus ENSPVAG00000002534 I 0.827
ENSPANG00000000982 Papio anubis ENSPANG00000000982 I 0.827
ZFX Oryctolagus cuniculus ENSOCUG00000003815 I 0.827
ZFX Microcebus murinus ENSMICG00000009517 I 0.827
ZFX Macaca mulatta ENSMMUG00000009801 I 0.827
ZFX Callithrix jacchus ENSCJAG00000004841 I 0.827
ZFX Dasypus novemcinctus ENSDNOG00000034569 I 0.827
ZFX Canis familiaris ENSCAFG00000013408 I 0.827
ZFY Bos taurus ENSBTAG00000007730 I 0.827
ENSAMEG00000012681 Ailuropoda melanoleuca ENSAMEG00000012681 I 0.827
ZFX Equus caballus ENSECAG00000025018 I 0.827
ENSCPOG00000011739 Cavia porcellus ENSCPOG00000011739 I 0.827
ZFX Felis catus ENSFCAG00000010544 I 0.827
ENSSHAG00000004983 Sarcophilus harrisii ENSSHAG00000004983 I 0.826
ENSSSCG00000012179 Sus scrofa ENSSSCG00000012179 I 0.826
ZFX Monodelphis domestica ENSMODG00000007512 I 0.826
ENSCSAG00000018321 Chlorocebus sabaeus ENSCSAG00000018321 I 0.823
ZFX Loxodonta africana ENSLAFG00000006691 I 0.821
ZFY Pan troglodytes ENSPTRG00000022471 I 0.820
ZFY Homo sapiens ENSG00000067646 I 0.817
ZFX Gorilla gorilla ENSGGOG00000004053 I 0.809
ZFX Homo sapiens ENSG00000005889 D 0.809
ENSPPYG00000020195 Pongo abelii ENSPPYG00000020195 I 0.809
ZFX Pan troglodytes ENSPTRG00000021747 I 0.809
Zfx Rattus norvegicus ENSRNOG00000005624 I 0.806
Zfx Mus musculus ENSMUSG00000079509 D 0.804
ENSTSYG00000005088 Tarsius syrichta ENSTSYG00000005088 I 0.788
Pvit_09540 Pogona vitticeps Pvit_09540 I 0.787
Ogr18022 Ophisaurus gracilis Ogr18022 I 0.785
ENSACAG00000007227 Anolis carolinensis ENSACAG00000007227 I 0.785
ZFX Ornithorhynchus anatinus ENSOANG00000011502 I 0.771