ENSP00000311816 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000311816 T135066_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
REST
M08084_2.00
Homo sapiens
GSHGCTGTCCRWGGTSCTGAH

DTCAGSACCWYGGACAGCDSC
ChIP-seq
Mathelier et al.(2014)
MA0138.2
0.827 1.000
REST
M07846_2.00
Homo sapiens
TCCVHGGTGCTGAM

KTCAGCACCDBGGA
ChIP-seq
Gerstein et al.(2012)
GM12878_NRSF_HudsonAlpha
0.827 1.000
REST
M07847_2.00
Homo sapiens
GCTGTCCRHGGTGCT

AGCACCDYGGACAGC
ChIP-seq
Gerstein et al.(2012)
H1-hESC_NRSF_HudsonAlpha
0.827 1.000
REST
M07848_2.00
Homo sapiens
HGCTGTCCRWGGTSCT

AGSACCWYGGACAGCD
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_NRSF_HudsonAlpha
0.827 1.000
REST
M07849_2.00
Homo sapiens
TGTCCRHGGTGCTGA

TCAGCACCDYGGACA
ChIP-seq
Gerstein et al.(2012)
HepG2_NRSF_HudsonAlpha
0.827 1.000
REST
M07850_2.00
Homo sapiens
TGTCCVHGGTGCTGA

TCAGCACCDBGGACA
ChIP-seq
Gerstein et al.(2012)
HTB-11_NRSF_HudsonAlpha
0.827 1.000
REST
M07851_2.00
Homo sapiens
CTGTCCVHGGTGCTGA

TCAGCACCDBGGACAG
ChIP-seq
Gerstein et al.(2012)
K562_NRSF_HudsonAlpha
0.827 1.000
REST
M07852_2.00
Homo sapiens
GSHGCTGTCCRHGGTGCTGAM

KTCAGCACCDYGGACAGCDSC
ChIP-seq
Gerstein et al.(2012)
PANC-1_NRSF_HudsonAlpha
0.827 1.000
REST
M07853_2.00
Homo sapiens
CTGTCCRHGGTGCTG

CAGCACCDYGGACAG
ChIP-seq
Gerstein et al.(2012)
PFSK-1_NRSF_HudsonAlpha
0.827 1.000
REST
M07854_2.00
Homo sapiens
GSHGCTGTCCRHGGT

ACCDYGGACAGCDSC
ChIP-seq
Gerstein et al.(2012)
U87_NRSF_HudsonAlpha
0.827 1.000
REST
M08861_2.00
Homo sapiens
DGSHGCTGTCCRHGGTGCTGAH

DTCAGCACCDYGGACAGCDSCH
Misc
Kulakovskiy et al.(2013)
REST_HUMAN.H11MO.0.A
0.827 1.000
REST
M09501_2.00
Homo sapiens
GGHGCTGTCCRWGGTGCTGA

TCAGCACCWYGGACAGCDCC
Misc
Heinz et al.(2010)
Jurkat-NRSF
0.827 1.000
REST
M10116_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NRSE_B
0.827 1.000
REST
M10117_2.00
Homo sapiens
GSYKCTGTCCGYGGTGCTGAA

TTCAGCACCRCGGACAGMRSC
Transfac
Matys et al.(2006)
V$NRSF_01
0.827 1.000
REST
M10118_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$REST_01
0.827 1.000
REST
M10119_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$REST_04
0.827 1.000
REST
M10120_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$REST_05
0.827 1.000
REST
M10121_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$REST_06
0.827 1.000
REST
M10122_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$REST_10
0.827 1.000
REST
M10123_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$REST_12
0.827 1.000
REST
M10124_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$REST_Q5
0.827 1.000
Rest
M10362_2.00
Rattus norvegicus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NRSF_Q4
0.826 0.988
Rest
M08983_2.00
Mus musculus
DGBHGCTGTCCDHGGTSCTGRH

DYCAGSACCDHGGACAGCDVCH
Misc
Kulakovskiy et al.(2013)
REST_MOUSE.H11MO.0.A
0.820 0.981
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000311816 C2H2 ZF 216 238
ENSP00000311816 C2H2 ZF 248 270
ENSP00000311816 C2H2 ZF 276 298
ENSP00000311816 C2H2 ZF 304 326
ENSP00000311816 C2H2 ZF 332 355
ENSP00000311816 C2H2 ZF 361 383
ENSP00000311816 C2H2 ZF 389 412

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

57 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSOARG00000005019 Ovis aries ENSOARG00000005019 I 0.827
ENSOGAG00000015986 Otolemur garnettii ENSOGAG00000015986 I 0.827
REST Ochotona princeps ENSOPRG00000008088 I 0.827
ENSOARG00000004929 Ovis aries ENSOARG00000004929 I 0.827
ENSNLEG00000008836 Nomascus leucogenys ENSNLEG00000008836 I 0.827
REST Myotis lucifugus ENSMLUG00000014530 I 0.827
REST Macaca mulatta ENSMMUG00000018821 I 0.827
ENSPANG00000017819 Papio anubis ENSPANG00000017819 I 0.827
ENSPPYG00000014745 Pongo abelii ENSPPYG00000014745 I 0.827
REST Tupaia belangeri ENSTBEG00000014480 I 0.827
ENSBTAP00000039405-D1 Bos grunniens ENSBTAP00000039405-D1 I 0.827
ENSP00000311816-D1 Bos grunniens ENSP00000311816-D1 I 0.827
ENSSTOG00000007375 Ictidomys tridecemlineatus ENSSTOG00000007375 I 0.827
ENSSARG00000010385 Sorex araneus ENSSARG00000010385 I 0.827
REST Pan troglodytes ENSPTRG00000016087 I 0.827
REST Pteropus vampyrus ENSPVAG00000010391 I 0.827
ENSMICG00000017078 Microcebus murinus ENSMICG00000017078 I 0.827
REST Oryctolagus cuniculus ENSOCUG00000001776 I 0.827
ENSCSAG00000005119 Chlorocebus sabaeus ENSCSAG00000005119 I 0.827
REST Dasypus novemcinctus ENSDNOG00000049113 I 0.827
REST Callithrix jacchus ENSCJAG00000004081 I 0.827
ENSBTAG00000019359 Bos taurus ENSBTAG00000019359 I 0.827
ENSAMEG00000008541 Ailuropoda melanoleuca ENSAMEG00000008541 I 0.827
ENSBTAG00000011789 Bos taurus ENSBTAG00000011789 I 0.827
REST Felis catus ENSFCAG00000003904 I 0.827
REST Canis familiaris ENSCAFG00000002254 I 0.827
REST Homo sapiens ENSG00000084093 D 0.827
REST Gorilla gorilla ENSGGOG00000002165 I 0.827
Rest Rattus norvegicus ENSRNOG00000002074 D 0.826
REST Loxodonta africana ENSLAFG00000003195 I 0.825
REST Equus caballus ENSECAG00000022536 I 0.824
Myotis_brandtii_REST_10026791 Myotis brandtii Myotis_brandtii_REST_10026791 I 0.821
REST Erinaceus europaeus ENSEEUG00000001134 I 0.820
Rest Mus musculus ENSMUSG00000029249 D 0.820
REST Sus scrofa ENSSSCG00000023357 I 0.808
ENSSSCG00000008893 Sus scrofa ENSSSCG00000008893 I 0.808
REST Anolis carolinensis ENSACAG00000002355 I 0.786
Pvit_05779 Pogona vitticeps Pvit_05779 I 0.786
Alligator_sinensis_CCG021969.1 Alligator sinensis Alligator_sinensis_CCG021969.1 I 0.782
Brh_R004325 Buceros rhinoceros Brh_R004325 I 0.782
ENSMGAG00000008536 Meleagris gallopavo ENSMGAG00000008536 I 0.782
Tal_R011864 Tyto alba Tal_R011864 I 0.782
Gfo_R000933 Geospiza fortis Gfo_R000933 I 0.782
Afo_R012862 Aptenodytes forsteri Afo_R012862 I 0.782
ENSAPLG00000009372 Anas platyrhynchos ENSAPLG00000009372 I 0.782
ENSTGUG00000004749 Taeniopygia guttata ENSTGUG00000004749 I 0.782
ENSPSIG00000002988 Pelodiscus sinensis ENSPSIG00000002988 I 0.782
ENSFALG00000006682 Ficedula albicollis ENSFALG00000006682 I 0.782
ENSGALG00000011390 Gallus gallus ENSGALG00000011390 I 0.782
ENSSHAG00000016270 Sarcophilus harrisii ENSSHAG00000016270 I 0.780
ENSMEUG00000010330 Macropus eugenii ENSMEUG00000010330 I 0.780
ENSMODG00000020702 Monodelphis domestica ENSMODG00000020702 I 0.779
Aan_R014984 Calypte anna Aan_R014984 I 0.775
rest.S Xenopus laevis XB-GENE-955471 I 0.767
rest Xenopus tropicalis XB-GENE-955466 I 0.765
rest.L Xenopus laevis XB-GENE-6256442 I 0.763
rest Danio rerio ENSDARG00000103046 I 0.760