ENSP00000342019 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000342019 T135203_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZNF189
M08244_2.00 		Homo sapiens
TGGAAAA
TTTTCCA		 ChIP-seq
Najafabadi et al.(2015b)
ZNF189 		0.826 0.997
ZNF189
M08311_2.00 		Homo sapiens
VDGGAASRGMVDNDSNNN
NNNSHNHBKCYSTTCCHB		 ChIP-seq
Schmitges et al.(2016)
O75820_5-10.RCADE 		0.826 0.997
ZNF189
M07589_2.00 		Homo sapiens
NBKCBSTTCCHB
VDGGAASVGMVN		 ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF189.RCADE.ReprocessedData 		0.826 0.997
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000342019 C2H2 ZF 148 170
ENSP00000342019 C2H2 ZF 176 198
ENSP00000342019 C2H2 ZF 204 226
ENSP00000342019 C2H2 ZF 232 254
ENSP00000342019 C2H2 ZF 260 282
ENSP00000342019 C2H2 ZF 288 310
ENSP00000342019 C2H2 ZF 316 338
ENSP00000342019 C2H2 ZF 344 366
ENSP00000342019 C2H2 ZF 372 394
ENSP00000342019 C2H2 ZF 400 422
ENSP00000342019 C2H2 ZF 456 478
ENSP00000342019 C2H2 ZF 484 506
ENSP00000342019 C2H2 ZF 512 534
ENSP00000342019 C2H2 ZF 540 562
ENSP00000342019 C2H2 ZF 568 590
ENSP00000342019 C2H2 ZF 599 621

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

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36 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action