ENSP00000342019 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000342019 T135203_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF189
M08244_2.00
Homo sapiens
TGGAAAA

TTTTCCA
ChIP-seq
Najafabadi et al.(2015b)
ZNF189
0.826 0.997
ZNF189
M08311_2.00
Homo sapiens
VDGGAASRGMVDNDSNNN

NNNSHNHBKCYSTTCCHB
ChIP-seq
Schmitges et al.(2016)
O75820_5-10.RCADE
0.826 0.997
ZNF189
M07589_2.00
Homo sapiens
NBKCBSTTCCHB

VDGGAASVGMVN
ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF189.RCADE.ReprocessedData
0.826 0.997
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000342019 C2H2 ZF 148 170
ENSP00000342019 C2H2 ZF 176 198
ENSP00000342019 C2H2 ZF 204 226
ENSP00000342019 C2H2 ZF 232 254
ENSP00000342019 C2H2 ZF 260 282
ENSP00000342019 C2H2 ZF 288 310
ENSP00000342019 C2H2 ZF 316 338
ENSP00000342019 C2H2 ZF 344 366
ENSP00000342019 C2H2 ZF 372 394
ENSP00000342019 C2H2 ZF 400 422
ENSP00000342019 C2H2 ZF 456 478
ENSP00000342019 C2H2 ZF 484 506
ENSP00000342019 C2H2 ZF 512 534
ENSP00000342019 C2H2 ZF 540 562
ENSP00000342019 C2H2 ZF 568 590
ENSP00000342019 C2H2 ZF 599 621

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

36 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000000647 Ailuropoda melanoleuca ENSAMEG00000000647 I 0.826
ENSCAFG00000002596 Canis familiaris ENSCAFG00000002596 I 0.825
ENSCSAG00000011204 Chlorocebus sabaeus ENSCSAG00000011204 I 0.827
ENSGGOG00000003650 Gorilla gorilla ENSGGOG00000003650 I 0.826
ENSMPUG00000006908 Mustela putorius furo ENSMPUG00000006908 I 0.774
ENSNLEG00000017115 Nomascus leucogenys ENSNLEG00000017115 I 0.826
ENSOARG00000007528 Ovis aries ENSOARG00000007528 I 0.825
ENSP00000324598-D52 Bos grunniens ENSP00000324598-D52 I 0.825
ENSPANG00000025675 Papio anubis ENSPANG00000025675 I 0.827
ENSPPYG00000019452 Pongo abelii ENSPPYG00000019452 I 0.826
ENSSSCG00000028757 Sus scrofa ENSSSCG00000028757 I 0.826
ENSSTOG00000024337 Ictidomys tridecemlineatus ENSSTOG00000024337 I 0.764
ENSTSYG00000002391 Tarsius syrichta ENSTSYG00000002391 I 0.826
Myotis_brandtii_ZNF189_10019383 Myotis brandtii Myotis_brandtii_ZNF189_10019383 I 0.822
Zfp189 Mus musculus ENSMUSG00000039634 I 0.817
Zfp189 Rattus norvegicus ENSRNOG00000006972 I 0.817
ZNF189 Pan troglodytes ENSPTRG00000021200 I 0.826
ZNF189 Pteropus vampyrus ENSPVAG00000000937 I 0.825
ZNF189 Sorex araneus ENSSARG00000013112 I 0.825
ZNF189 Cavia porcellus ENSCPOG00000015555 I 0.772
ZNF189 Callithrix jacchus ENSCJAG00000016305 I 0.826
ZNF189 Choloepus hoffmanni ENSCHOG00000005577 I 0.773
ZNF189 Tursiops truncatus ENSTTRG00000014352 I 0.771
ZNF189 Bos taurus ENSBTAG00000015348 I 0.825
ZNF189 Dasypus novemcinctus ENSDNOG00000013049 I 0.773
ZNF189 Equus caballus ENSECAG00000015455 I 0.823
ZNF189 Myotis lucifugus ENSMLUG00000006015 I 0.822
ZNF189 Macaca mulatta ENSMMUG00000023795 I 0.827
ZNF189 Loxodonta africana ENSLAFG00000016551 I 0.824
ZNF189 Homo sapiens ENSG00000136870 D 0.826
ZNF189 Felis catus ENSFCAG00000026510 I 0.825
ZNF189 Erinaceus europaeus ENSEEUG00000004869 I 0.804
ZNF189 Oryctolagus cuniculus ENSOCUG00000014941 I 0.826
ZNF189 Otolemur garnettii ENSOGAG00000028518 I 0.826
ZNF189 Ochotona princeps ENSOPRG00000015563 I 0.804
ZNF189 Microcebus murinus ENSMICG00000011446 I 0.826