ENSP00000371398 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000371398 T135363_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
GLIS3
M02880_2.00 		Homo sapiens
CTTYGTGGGGGGTM
KACCCCCCACRAAG		 SELEX
Jolma et al.(2013)
GLIS3_1 		0.827 0.982
GLIS3
M10169_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZNF515_01 		0.827 0.982
GLIS3
M10170_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZNF515_Q6_01 		0.827 0.982
GLIS3
M10171_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZNF515_Q6 		0.827 0.982
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000371398 C2H2 ZF 501 526
ENSP00000371398 C2H2 ZF 535 562
ENSP00000371398 C2H2 ZF 569 592
ENSP00000371398 C2H2 ZF 598 622
ENSP00000371398 C2H2 ZF 628 652

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

Invalid Input OrderBy

80 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action