ENSP00000379255-D1 (Bos grunniens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000379255-D1 T135415_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000379255-D1 C2H2 ZF 14 41
ENSP00000379255-D1 C2H2 ZF 47 71
ENSP00000379255-D1 C2H2 ZF 77 102
ENSP00000379255-D1 C2H2 ZF 108 133

Links

Other C2H2 ZF family TFs
Other Bos grunniens TFs

23 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Alligator_sinensis_CCG001512.1 Alligator sinensis Alligator_sinensis_CCG001512.1 N 0.827
ENSTGUG00000014304 Taeniopygia guttata ENSTGUG00000014304 N 0.827
Myotis_brandtii_GLI3_10009944 Myotis brandtii Myotis_brandtii_GLI3_10009944 N 0.827
Ogr17074 Ophisaurus gracilis Ogr17074 N 0.827
ENSPMAG00000007806 Petromyzon marinus ENSPMAG00000007806 N 0.822
Brh_R006636 Buceros rhinoceros Brh_R006636 N 0.821
Aan_R000709 Calypte anna Aan_R000709 N 0.821
Alligator_sinensis_CCG009321.1 Alligator sinensis Alligator_sinensis_CCG009321.1 N 0.821
gli2 Xenopus tropicalis XB-GENE-481810 N 0.815
gli2b Oryzias latipes ENSORLG00000001328 N 0.813
ENSORLG00000015277 Oryzias latipes ENSORLG00000015277 N 0.812
Cflo_10733--XP_624136.2_APIME Camponotus floridanus Cflo_10733--XP_624136.2_APIME N 0.810
ACYPI45156 Acyrthosiphon pisum ACYPI45156 N 0.798
ACEP11153 Atta cephalotes ACEP11153 N 0.798
SROB_0000648801 Schistosoma rodhaini SROB_0000648801 N 0.795
SMTD_0001685401 Schistosoma mattheei SMTD_0001685401 N 0.795
GLI2 Tupaia belangeri ENSTBEG00000008264 N 0.795
SMRZ_0000087601 Schistosoma margrebowiei SMRZ_0000087601 N 0.792
TMUE_s0120001200 Trichuris muris TMUE_s0120001200 N 0.780
ENSMICG00000005378 Microcebus murinus ENSMICG00000005378 N 0.779
SMU15013615 Schmidtea mediterranea SMU15013615 N 0.772
XP_002156924.1 Hydra magnipapillata XP_002156924.1 N 0.765
Aqu1.217717 Amphimedon queenslandica Aqu1.217717 N 0.762