ENSP00000380019 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000380019 T135431_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF384
M04451_2.00
Homo sapiens
TTTTBNNNNNNNNNNNNVAAAA

TTTTBNNNNNNNNNNNNVAAAA
SELEX
Yin et al.(2017)
ZNF384_eDBD_HT-SELEX
0.798 0.989
ZNF384
M08306_2.00
Homo sapiens
CTTTTTTTT

AAAAAAAAG
ChIP-seq
Schmitges et al.(2016)
Q8TF68_1-3.RCADE
0.798 0.989
ZNF384
M08090_2.00
Homo sapiens
WTTTTTTTNHNN

NNDNAAAAAAAW
ChIP-seq
Mathelier et al.(2014)
MA1125.1
0.798 0.989
ZNF384
M08888_2.00
Homo sapiens
BVNNBTTTTTSC

GSAAAAAVNNBV
Misc
Kulakovskiy et al.(2013)
ZN384_HUMAN.H11MO.0.C
0.798 0.989
ZNF384
M10209_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CIZ_01
0.798 0.989
ZNF384
M04452_2.00
Homo sapiens
KTTTYHNNNNNNNNNNDRAAAV

BTTTYHNNNNNNNNNNDRAAAM
SELEX
Yin et al.(2017)
ZNF384_eDBD_Methyl-HT-SELEX
0.798 0.989
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000380019 C2H2 ZF 228 250
ENSP00000380019 C2H2 ZF 256 278
ENSP00000380019 C2H2 ZF 284 306
ENSP00000380019 C2H2 ZF 317 339
ENSP00000380019 C2H2 ZF 345 367
ENSP00000380019 C2H2 ZF 373 397
ENSP00000380019 C2H2 ZF 403 425
ENSP00000380019 C2H2 ZF 433 455

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

37 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000014121 Ailuropoda melanoleuca ENSAMEG00000014121 I 0.798
ENSNLEG00000004506 Nomascus leucogenys ENSNLEG00000004506 I 0.798
ENSMPUG00000016838 Mustela putorius furo ENSMPUG00000016838 I 0.798
ZNF384 Macaca mulatta ENSMMUG00000016990 I 0.798
ZNF384 Loxodonta africana ENSLAFG00000008381 I 0.798
ZNF384 Oryctolagus cuniculus ENSOCUG00000003747 I 0.798
ZNF384 Otolemur garnettii ENSOGAG00000010052 I 0.798
ENSPPYG00000004196 Pongo abelii ENSPPYG00000004196 I 0.798
ZNF384 Procavia capensis ENSPCAG00000012951 I 0.798
ENSPANG00000014845 Papio anubis ENSPANG00000014845 I 0.798
ZNF384 Ochotona princeps ENSOPRG00000003626 I 0.798
ZNF384 Pan troglodytes ENSPTRG00000004584 I 0.798
ZNF384 Gorilla gorilla ENSGGOG00000016048 I 0.798
ENSSTOG00000009902 Ictidomys tridecemlineatus ENSSTOG00000009902 I 0.798
ENSCSAG00000010379 Chlorocebus sabaeus ENSCSAG00000010379 I 0.798
ZNF384 Callithrix jacchus ENSCJAG00000007944 I 0.798
ZNF384 Canis familiaris ENSCAFG00000014740 I 0.798
ZNF384 Homo sapiens ENSG00000126746 D 0.798
ZNF384 Sus scrofa ENSSSCG00000000702 I 0.798
ZNF384 Felis catus ENSFCAG00000006882 I 0.798
ZNF384 Myotis lucifugus ENSMLUG00000013771 I 0.797
Myotis_brandtii_ZNF384_10009390 Myotis brandtii Myotis_brandtii_ZNF384_10009390 I 0.797
ZNF384 Choloepus hoffmanni ENSCHOG00000006697 I 0.796
ZNF384 Erinaceus europaeus ENSEEUG00000012950 I 0.791
ZNF384 Pteropus vampyrus ENSPVAG00000011440 I 0.787
Zfp384 Rattus norvegicus ENSRNOG00000017066 I 0.781
Zfp384 Mus musculus ENSMUSG00000038346 I 0.781
Cmyd_10003951 Chelonia mydas Cmyd_10003951 I 0.779
Alligator_sinensis_CCG002534.1 Alligator sinensis Alligator_sinensis_CCG002534.1 I 0.779
ENSFALG00000004741 Ficedula albicollis ENSFALG00000004741 I 0.779
ZNF384 Monodelphis domestica ENSMODG00000018105 I 0.775
ENSSHAG00000015330 Sarcophilus harrisii ENSSHAG00000015330 I 0.775
ZNF384 Bos taurus ENSBTAG00000017072 I 0.769
ENSBTAP00000022702-D1 Bos grunniens ENSBTAP00000022702-D1 I 0.769
ZNF384 Dasypus novemcinctus ENSDNOG00000003936 I 0.769
ZNF384 Equus caballus ENSECAG00000009490 I 0.769
ZNF384 Tursiops truncatus ENSTTRG00000011754 I 0.769